Cysmethynil

• 常用名: Cysmethynil
• 英文名: Cysmethynil
• CAS号: 851636-83-4
• 分子量: 376.53400
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₃₂N₂O
• 熔点: N/A
• 闪点: N/A

Cysmethynil用途

Cysmethynil 是一种 Icmt 抑制剂(IC50 = 2.4 μM)。Cysmethynil 抑制 RAS 膜结合和EGF的信号转导。Cysmethynil 将细胞周期阻滞在 G1 期,诱导细胞自噬。Cysmethynil 抑制 PC3 细胞增殖,与 Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A) 有协同作用。Cysmethynil 具有抗肿瘤作用,可用于实体瘤 (例如前列腺癌等) 研究。

Cysmethynil名称

• 中文名: 嘧啶
• 英文名: 2-[5-(3-methylphenyl)-1-octylindol-3-yl]acetamide

Cysmethynil生物活性

• 描述: Cysmethynil 是一种 Icmt 抑制剂(IC50 = 2.4 μM)。Cysmethynil 抑制 RAS 膜结合和EGF的信号转导。Cysmethynil 将细胞周期阻滞在 G1 期,诱导细胞自噬。Cysmethynil 抑制 PC3 细胞增殖,与 Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A) 有协同作用。Cysmethynil 具有抗肿瘤作用,可用于实体瘤 (例如前列腺癌等) 研究。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 自噬 >> 自噬
• 靶点实验:

  IC50 = 2.4 μM for Icmt

• 参考文献:

  [1]. Winter-Vann AM, et al. A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4336-41.

  [2]. Wang M, et al. A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. J Biol Chem. 2008 Jul 4;283(27):18678-84.

  [3]. Pan Q, et al. Inhibition of isoprenylcysteine carboxylmethyltransferase sensitizes common chemotherapies in cervical cancer via Ras-dependent pathway. Biomed Pharmacother. 2018 Mar;99:169-175.

  [4]. Zhu C, et al. Targeting KRAS mutant cancers: from druggable therapy to drug resistance. Mol Cancer. 2022 Aug 4;21(1):159.

Cysmethynil物理化学性质

• 分子式: C₂₅H₃₂N₂O
• 分子量: 376.53400
• 精确质量: 376.25100
• PSA: 49.01000
• LogP: 7.15470
• InChIKey: QIXBOOVPFRZHQQ-UHFFFAOYSA-N
• SMILES: CCCCCCCCn1cc(CC(N)=O)c2cc(-c3cccc(C)c3)ccc21
• 储存条件: -20°C，密闭，干燥

Cysmethynil靶点实验

查看更多实验

实验名称：Inhibition of ICMT in human PC3 cells assessed as induction of mislocalization of end... 来源：ChEMBL 靶标：Protein-S-isoprenylcysteine O-methyltransferase External Id：CHEMBL4360145

实验名称：Induction of autophagy in human PC3 cells assessed as increase in LC3 expression at 2... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL4360154

实验名称：Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as tr... 来源：ChEMBL 靶标：Protein-S-isoprenylcysteine O-methyltransferase External Id：CHEMBL2380129

实验名称：Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL2380128

实验名称：Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL2380127

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by colorimetri... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL1259549

实验名称：Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins... 来源：ChEMBL 靶标：Protein-S-isoprenylcysteine O-methyltransferase External Id：CHEMBL1259548

实验名称：Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase... 来源：NCGC External Id：GPx1-biochemical-p4-p7

共30条，当前第1页，共3页

1

2

3

Cysmethynil英文别名

• 9J20
• 2-[5-(3-Methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
• Cysmethynil
• 1H-Indole-3-acetamide,5-(3-methylphenyl)-1-octyl