FLT3 Inhibitor III

• 常用名: FLT3 Inhibitor III
• 英文名: Flt-3 Inhibitor III
• CAS号: 852045-46-6
• 分子量: 365.492
• 密度: 1.2±0.1 g/cm3
• 沸点: 554.1±60.0 °C at 760 mmHg
• 分子式: C₂₁H₂₃N₃OS
• 熔点: N/A
• 闪点: 288.9±32.9 °C

FLT3 Inhibitor III用途

Flt-3抑制剂III是一种有效且选择性的FLT3激酶抑制剂,其50为50nM。Flt-3抑制剂III对其他激酶的活性较弱。Flt-3抑制剂III具有抗癌作用[1]。

FLT3 Inhibitor III名称

• 中文名: FLT3 Inhibitor III
• 英文名: FLT3 Inhibitor III

FLT3 Inhibitor III生物活性

• 描述: Flt-3抑制剂III是一种有效且选择性的FLT3激酶抑制剂,其50为50nM。Flt-3抑制剂III对其他激酶的活性较弱。Flt-3抑制剂III具有抗癌作用[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> FLT3
• 靶点实验:

  IC50: 50 nM (FLT3 kinase)[1]

• 体外研究: Flt-3抑制剂III(化合物 4)也抑制 c-Kit、KDR、c-Abl、CDK1、c-Src和 铁-2,IC50值分别为 0.26µM、0.91µM、1.2µM、2.1µM、2.8µM和 8.0µM[1]Flt-3抑制剂III(化合物 4)阻断 BaF3 ITD、BaF3-D835/Y和 MV4:11细胞的增殖,国际50值分别为 0.24µM、0.76µM和 0.052µM[1]
• 参考文献:

  [1]. Pascal Furet, et al. Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents. J Med Chem. 2006 Jul 27;49(15):4451-4.

FLT3 Inhibitor III物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 554.1±60.0 °C at 760 mmHg
• 分子式: C₂₁H₂₃N₃OS
• 分子量: 365.492
• 闪点: 288.9±32.9 °C
• 精确质量: 365.156189
• LogP: 4.48
• InChIKey: FNZTULJDGIXMJJ-UHFFFAOYSA-N
• SMILES: c1ccc(-c2cnc(Nc3ccc(OCCN4CCCC4)cc3)s2)cc1
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.640
• 储存条件: -20°C，密闭，干燥

FLT3 Inhibitor III安全信息

FLT3 Inhibitor III靶点实验

查看更多实验

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219380

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219381

实验名称：Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219378

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to contro... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219379

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 10uM relative to contr... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2218943

实验名称：Millipore: Percentage of residual kinase activity of ABL1 at 1uM relative to control.... 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL2218944

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 10uM relative to contro... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219382

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 1uM relative to contro... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2219383

实验名称：Millipore: Percentage of residual kinase activity of TNK2 at 10uM relative to control... 来源：ChEMBL 靶标：Activated CDC42 kinase 1 External Id：CHEMBL2219372

共491条，当前第1页，共50页

1

2

3

4

5

FLT3 Inhibitor III英文别名

• FLT3 Inhibitor III
• 5-Phenyl-N-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1,3-thiazol-2-amine
• Flt-3 Inhibitor III