Necrostatin 2外消旋体

• 常用名: Necrostatin 2外消旋体
• 英文名: 7-Cl-O-Nec1
• CAS号: 852391-15-2
• 分子量: 277.706
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₃H₁₂ClN₃O₂
• 熔点: N/A
• 闪点: N/A

Necrostatin 2外消旋体用途

Necrostatin 2是高活性的坏死性凋亡抑制剂,EC50为50nM。

Necrostatin 2外消旋体名称

• 中文名: Necrostatin 2外消旋体
• 英文名: 2,4-Imidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl

Necrostatin 2外消旋体生物活性

• 描述: Necrostatin 2是高活性的坏死性凋亡抑制剂,EC50为50nM。
• 相关类别:
  信号通路 >> 细胞凋亡 >> TNF受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Teng X, Keys H, Jeevanandam A, Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6836-40.

  [2]. Jagtap PG, Degterev A, Choi S, Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem. 2007 Apr 19;50(8):1886-95.

  [3]. Teng X, Degterev A, Jagtap P, Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5039-44.

Necrostatin 2外消旋体物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₁₃H₁₂ClN₃O₂
• 分子量: 277.706
• 精确质量: 277.061798
• PSA: 65.20000
• LogP: 1.76
• InChIKey: WIKGAEMMNQTUGL-UHFFFAOYSA-N
• SMILES: CN1C(=O)NC(Cc2c[nH]c3c(Cl)cccc23)C1=O
• 外观性状: 粉末
• 折射率: 1.676
• 储存条件: -20℃

Necrostatin 2外消旋体靶点实验

查看更多实验

实验名称：Time taken to reach maximum concentration in female mouse upon intravenous administra... 来源：ChEMBL 靶标：N/A External Id：CHEMBL880486

实验名称：Confirmatory qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinas... 来源：NCGC External Id：IP6K1-f1-cherrypicks

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Inhibition of necroptosis in icv dosed mouse middle cerebral artery occlusion induced... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1266010

实验名称：Inhibition of necroptosis in icv dosed mouse middle cerebral artery occlusion induced... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1266009

实验名称：Protection against TNF-induced death in TNF-induced SIRS C57BL/6J mouse model at 50 m... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4048567

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Necrostatin 2外消旋体英文别名

• (5R)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione
• Necrostatin 2 (racemate)
• (5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione
• Necrostatin 2 racemate