CID11210285 盐酸盐

• 常用名: CID11210285 盐酸盐
• 英文名: BML 284
• CAS号: 853220-52-7
• 分子量: 350.371
• 密度: 1.4±0.1 g/cm3
• 沸点: 623.4±65.0 °C at 760 mmHg
• 分子式: C₁₉H₁₈N₄O₃
• 熔点: N/A
• 闪点: 330.8±34.3 °C

CID11210285 盐酸盐用途

BML-284是选择性和可渗透细胞的Wnt信号传导激活剂。

CID11210285 盐酸盐名称

• 中文名: CID11210285 盐酸盐
• 英文名: N4-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine

CID11210285 盐酸盐生物活性

• 描述: BML-284是选择性和可渗透细胞的Wnt信号传导激活剂。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> Wnt信号
  研究领域 >> 癌症
• 参考文献:

  [1]. Liu J, et al. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005 Mar 18;44(13):1987-90.

  [2]. Wang H, et al. 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes. Inflamm Res. 2016 Jan;65(1):61-9.

CID11210285 盐酸盐物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 623.4±65.0 °C at 760 mmHg
• 分子式: C₁₉H₁₈N₄O₃
• 分子量: 350.371
• 闪点: 330.8±34.3 °C
• 精确质量: 350.137878
• LogP: 3.72
• InChIKey: FABQUVYDAXWUQP-UHFFFAOYSA-N
• SMILES: COc1cccc(-c2cc(NCc3ccc4c(c3)OCO4)nc(N)n2)c1
• 外观性状: 粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.684
• 储存条件: -20℃

CID11210285 盐酸盐靶点实验

查看更多实验

实验名称：Induction of Beta tubulin degradation in human HCT-116 cells incubated for 24 hrs by ... 来源：ChEMBL 靶标：Tubulin beta 8B External Id：CHEMBL5149026

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Induction of Alpha tubulin degradation in human HCT-116 cells incubated for 24 hrs by... 来源：ChEMBL 靶标：Tubulin alpha-3C chain External Id：CHEMBL5149025

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Antiproliferative activity against human HeLa cells assessed as reduction in cell via... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5545228

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Antiproliferative activity against human HCT-116 cells assessed as reduction in cell ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5545229

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CID11210285 盐酸盐英文别名

• N-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine
• MFCD09908087
• BML-284
• Wnt agonist 1
• CID 11210285 hydrochloride