Vialinin A

• 常用名: Vialinin A
• 英文名: Vialinin A
• CAS号: 858134-23-3
• 分子量: 562.57
• 密度: 1.4±0.1 g/cm3
• 沸点: 846.9±65.0 °C at 760 mmHg
• 分子式: C₃₄H₂₆O₈
• 熔点: N/A
• 闪点: 277.1±27.8 °C

Vialinin A用途

Vialinin A(Terrestrin A)是一种具有抗氧化性能的对三苯基化合物[1]。Vialinin A是TNF-α、USP4、USP5和sentrin/SUMO特异性蛋白酶1(SENP1)的有效抑制剂。Vialinin A(Terrestrin A)可用于自身免疫性疾病和癌症研究[2][3]。

Vialinin A名称

• 中文名: Vialinin A
• 英文名: [3,4-dihydroxy-2,5-bis(4-hydroxyphenyl)-6-(2-phenylacetyl)oxyphenyl] 2-phenylacetate

Vialinin A生物活性

• 描述: Vialinin A(Terrestrin A)是一种具有抗氧化性能的对三苯基化合物[1]。Vialinin A是TNF-α、USP4、USP5和sentrin/SUMO特异性蛋白酶1(SENP1)的有效抑制剂。Vialinin A(Terrestrin A)可用于自身免疫性疾病和癌症研究[2][3]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 去泛素化酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Ji-Kai Liu, et al. Natural terphenyls: developments since 1877. Chem Rev. 2006 Jun;106(6):2209-23.

  [2]. Jie Xu, et al. Ubiquitously specific protease 4 inhibitor-Vialinin A attenuates inflammation and fibrosis in S100-induced hepatitis mice through Rheb/mTOR signalling.J Cell Mol Med. 2021 Jan;25(2):1140-1150.

  [3]. Himangshu Sonowal,et al. Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo. Oxid Med Cell Longev. 2018 Feb 6;2018:1052102.

Vialinin A物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 846.9±65.0 °C at 760 mmHg
• 分子式: C₃₄H₂₆O₈
• 分子量: 562.57
• 闪点: 277.1±27.8 °C
• 精确质量: 562.162781
• PSA: 133.52000
• LogP: 4.58
• InChIKey: NOJUKCRPSUMHQQ-UHFFFAOYSA-N
• SMILES: O=C(Cc1ccccc1)Oc1c(OC(=O)Cc2ccccc2)c(-c2ccc(O)cc2)c(O)c(O)c1-c1ccc(O)cc1
• 蒸汽压: 0.0±3.3 mmHg at 25°C
• 折射率: 1.677
• 储存条件: -20°C，密闭，干燥

Vialinin A靶点实验

查看更多实验

实验名称：Competitive binding affinity to human USP5 C335A mutant by SDS-PAGE analysis in prese... 来源：ChEMBL 靶标：Ubiquitin carboxyl-terminal hydrolase 5 External Id：CHEMBL2412078

实验名称：Competitive binding affinity to human USP5 H818A mutant by SDS-PAGE analysis in prese... 来源：ChEMBL 靶标：Ubiquitin carboxyl-terminal hydrolase 5 External Id：CHEMBL2412077

实验名称：Competitive binding affinity to human USP5 C335A/H818A mutant by SDS-PAGE analysis in... 来源：ChEMBL 靶标：Ubiquitin carboxyl-terminal hydrolase 5 External Id：CHEMBL2412076

实验名称：Inhibition of wild type human USP5 expressed in Escherichia coli BL21(DE3) using K48-... 来源：ChEMBL 靶标：Ubiquitin carboxyl-terminal hydrolase 5 External Id：CHEMBL2412075

实验名称：Binding affinity to USP5 in rat RBL2H3 cell extracts at 10 to 40 uM by SDS-PAGE analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2412082

实验名称：Competitive binding affinity to human recombinant USP5 after 1 hr by SDS-PAGE analysi... 来源：ChEMBL 靶标：Ubiquitin carboxyl-terminal hydrolase 5 External Id：CHEMBL2412079

实验名称：Inhibition of human UCH-L3 using Ub-AMC as substrate at 1 to 30 uM after 60 mins by f... 来源：ChEMBL 靶标：Ubiquitin carboxyl-terminal hydrolase isozyme L3 External Id：CHEMBL2411921

实验名称：Inhibition of human USP2 using Ub-AMC as substrate at 1 to 30 uM after 60 mins by flu... 来源：ChEMBL 靶标：Ubiquitin carboxyl-terminal hydrolase 2 External Id：CHEMBL2411919

实验名称：Inhibition of SENP1 in human KU812 cells preincubated for 20 mins followed by additio... 来源：ChEMBL 靶标：Sentrin-specific protease 1 External Id：CHEMBL4479675

实验名称：Inhibition of calpain1/2 (unknown origin) using Suc-LLVY-AMC as substrate at 6.3 uM a... 来源：ChEMBL 靶标：Calpain-2 catalytic subunit External Id：CHEMBL2411912

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Vialinin A英文别名

• 5',6'-bis(phenylacetoxy)-1,1':4',1''-terphenyl-2',3',4,4''-tetraol
• Vialinin A
• terrestrin A
• 4,5',6',4''-tetrahydroxy-2',3'-di(phenylacetoxy)-[1,1',4',1''-terphenyl]
• 4,4'',5',6'-Tetrahydroxy-1,1':4',1''-terphenyl-2',3'-diyl bis(phenylacetate)
• Benzeneacetic acid, 4,4'',5',6'-tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl ester