GR 125487 sulfamate

• 常用名: GR 125487 sulfamate
• 英文名: GR 125487 sulfamate
• CAS号: 859502-43-5
• 分子量: 524.58
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₉FN₄O₈S₂
• 熔点: N/A
• 闪点: N/A

GR 125487 sulfamate用途

GR125487 sulfamate 是有口服活性的 5-HT4R 选择性拮抗剂。GR125487 sulfamate 有效阻断认知增强作用。GR125487 sulfamate 可用于研究记忆障碍、胃肠障碍、情绪障碍、尿路功能障碍。

GR 125487 sulfamate名称

• 英文名: Sulfamic acid-(1-{2-[(methylsulfonyl)amino]ethyl}-4-piperidinyl )methyl 5-fluoro-2-methoxy-1H-indole-3-carboxylate (1:1)

GR 125487 sulfamate生物活性

• 描述: GR125487 sulfamate 是有口服活性的 5-HT4R 选择性拮抗剂。GR125487 sulfamate 有效阻断认知增强作用。GR125487 sulfamate 可用于研究记忆障碍、胃肠障碍、情绪障碍、尿路功能障碍。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 参考文献:

  [1]. Nirogi, R., et al. Synthesis of GR 125487, a selective 5-HT4receptor antagonist. Synthetic Communications, 46(12), 1036–1043.

GR 125487 sulfamate物理化学性质

• 分子式: C₁₉H₂₉FN₄O₈S₂
• 分子量: 524.58
• 精确质量: 524.14100
• PSA: 197.88000
• LogP: 3.67220
• InChIKey: VQJFDBXITIOGJM-UHFFFAOYSA-N
• SMILES: COc1[nH]c2ccc(F)cc2c1C(=O)OCC1CCN(CCNS(C)(=O)=O)CC1.NS(=O)(=O)O

GR 125487 sulfamate靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

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GR 125487 sulfamate英文别名

• [Ala92]-p16 (84-103)