普伐他汀类酯

• 常用名: 普伐他汀类酯
• 英文名: Pravastatin Lactone
• CAS号: 85956-22-5
• 分子量: 406.51
• 密度: 1.2±0.1 g/cm3
• 沸点: 590.5±50.0 °C at 760 mmHg
• 分子式: C₂₃H₃₄O₆
• 熔点: 140-143ºC
• 闪点: 199.5±23.6 °C

普伐他汀类酯用途

Pravastatin lactone 是一种有效的 HMG-CoA 抑制剂。Pravastatin lactone 是普伐他汀的代谢产物。Pravastatin lactone 通过抑制胆固醇合成来降低血液胆固醇水平。

普伐他汀类酯名称

• 中文名: 普伐他汀类酯
• 英文名: [(1S,3S,7S,8S,8aR)-3-hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
• 中文别名: 普伐他汀内酯 | 普伐他汀杂质D

普伐他汀类酯生物活性

• 描述: Pravastatin lactone 是一种有效的 HMG-CoA 抑制剂。Pravastatin lactone 是普伐他汀的代谢产物。Pravastatin lactone 通过抑制胆固醇合成来降低血液胆固醇水平。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
• 参考文献:

  [1]. Corsini A, et, al. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol Res. 1995 Jan;31(1):9-27.

普伐他汀类酯物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 590.5±50.0 °C at 760 mmHg
• 熔点: 140-143ºC
• 分子式: C₂₃H₃₄O₆
• 分子量: 406.51
• 闪点: 199.5±23.6 °C
• 精确质量: 406.235535
• PSA: 93.06000
• LogP: 1.71
• InChIKey: OQARDMYXSOFTLN-PZAWKZKUSA-N
• SMILES: CCC(C)C(=O)OC1CC(O)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C21
• 蒸汽压: 0.0±3.8 mmHg at 25°C
• 折射率: 1.548
• 储存条件: -20°C，密闭，干燥

普伐他汀类酯靶点实验

查看更多实验

实验名称：Potency index, ratio of simvastatin IC50 to test compound IC50 for inhibition of Myco... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5237929

实验名称：Increase the activity of the Burkholderia fixLJ 2-component system 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Burkholderia multivorans External Id：HMS1625

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：ORF 73 [Human herpesvirus 8 type M] External Id：HMS791

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS1303

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：Phenotypic Assay to Identify Small Molecules that Upregulate Production of hCFTR in H... 来源：Southern Research Institute 靶标：CFTR External Id：CF Folding

实验名称：MELAS cybrid survival enhancement under low glucose conditions 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1419

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普伐他汀类酯英文别名

• [14C]-Pravastatin lactone
• UNII:JBE3Z4192Q
• Pravastatin lactone
• Pravastatin sodium specified impurity D [EP]
• pravastatin
• UNII-JBE3Z4192Q
• (1S,3S,7S,8S,8aR)-3-Hydroxy-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate
• HMS2090H21