85956-22-5

• 常用中文名：普伐他汀类酯
• 常用英文名：Pravastatin Lactone
• CAS号：85956-22-5
• 分子式：C₂₃H₃₄O₆
• 分子量：406.51
• 相关类别： 信号通路 代谢酶/蛋白酶 HMG-CoA还原酶(HMGCR)
• 发布时间：2018-05-16 08:00:00
• 更新时间：2026-07-01 08:31:43
• Pravastatin lactone 是一种有效的 HMG-CoA 抑制剂。Pravastatin lactone 是普伐他汀的代谢产物。Pravastatin lactone 通过抑制胆固醇合成来降低血液胆固醇水平。

名称

• 中文名: 普伐他汀类酯
• 英文名: [(1S,3S,7S,8S,8aR)-3-hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
• 中文别名: 普伐他汀钠杂质Ⅲ(普伐他汀内酯); 普伐他汀钠杂质D 标准品; 普伐他汀杂质4(普伐他汀杂质D); 普伐他汀杂质04; 普伐他汀杂质D; 普伐他汀钠杂质D; 普伐他汀内酯; 普伐他汀杂质D /BP); 普伐他汀杂质D(普伐他汀内酯); 普伐他汀杂质10
• 英文别名: (1S)-1β-[2-[[(2R,4R)-3,4,5,6-Tetrahydro-4β-hydroxy-6-oxo-2H-pyran]-2-yl]ethyl]-1,2,6,7,8,8aβ-hexahydro-2β-methyl-8α-[[(S)-2-methyl-1-oxobutyl]oxy]naphthalen-6β-ol; [14C]-Pravastatin lactone; pravastatin; Pravastatin Impurity; (1S,3S,7S,8S,8-3-Hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-7-methyl-1; Pravastatin Lactone_x000b_; Pravastatin Impurity D (Pravastatin Lactone); Pravastatin Sodium Impurity Ⅲ:Pravastatin Impurity D (Pravastatin Lactone); Pravastatin Impurity10; (1S,3S,7S,8S,8-3-Hydroxy-8-[2-[(; Pravastatin IMpurity D; (2S)-2-Methyl-Butanoic Acid (1S,3S,7S,8S,8-1,2,3,7,8,8a-hexahydro-3-hydroxy-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester; Pravastatin lactone; Pravastatin sodium specified impurity D [EP]; (1S,3S,7S,8S,8-3-Hydroxy-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate; UNII-JBE3Z4192Q; PRAVASTATIN SODIUM(RG); Pravastatin class ester; Pravastatin Impurity 4（Pravastatin Impurity D）; Pravastatin LactoneQ: What is Pravastatin Lactone Q: What is the CAS Number of Pravastatin Lactone Q: What is the storage condition of Pravastatin Lactone; Butanoic acid, 2-methyl-, (1S,3S,7S,8S,8-1,2,3,7,8,8a-hexahydro-3-hydroxy-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S); UNII:JBE3Z4192Q; (1S,3S,7S,8S,8-3-Hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate; Pravastatin Sodium Impurity D; [(1S,3S,7S,8S,8-3-hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate; (1S,3S,7S,8S,8aR)-3-Hydroxy-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate; HMS2090H21

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 590.5±50.0 °C at 760 mmHg
• 熔点: 140-143ºC
• 分子式: C₂₃H₃₄O₆
• 分子量: 406.51
• 闪点: 199.5±23.6 °C
• 精确质量: 406.235535
• PSA: 93.06000
• LogP: 1.71
• 蒸汽压: 0.0±3.8 mmHg at 25°C
• 折射率: 1.548
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Pravastatin lactone 是一种有效的 HMG-CoA 抑制剂。Pravastatin lactone 是普伐他汀的代谢产物。Pravastatin lactone 通过抑制胆固醇合成来降低血液胆固醇水平。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
• 参考文献:

  [1]. Corsini A, et, al. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol Res. 1995 Jan;31(1):9-27.

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