23-羟基白桦酸

• 常用名: 23-羟基白桦酸
• 英文名: Anemosapogenin
• CAS号: 85999-40-2
• 分子量: 472.700
• 密度: 1.1±0.1 g/cm3
• 沸点: 585.8±25.0 °C at 760 mmHg
• 分子式: C₃₀H₄₈O₄
• 熔点: 305 °C
• 闪点: 322.1±19.7 °C

23-羟基白桦酸用途

23-hydroxybetulinic acid是具有抗癌活性的生物化合物。

23-羟基白桦酸名称

• 中文名: 23-羟基白桦酸
• 英文名: (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS,13bR)-9-hydroxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid

23-羟基白桦酸生物活性

• 描述: 23-hydroxybetulinic acid是具有抗癌活性的生物化合物。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
  天然产物 >> 酸和醛
• 参考文献:

  [1]. Liu M et al. Cytotoxicity of the compounds isolated from Pulsatilla chinensis saponins and apoptosis induced by 23-hydroxybetulinic acid. Pharm Biol. 2015 Jan;53(1):1-9.

  [2]. Zhang DM et al. BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo. Mol Pharm. 2012 Nov 5;9(11):3147-59.

  [3]. Zheng Y et al. 23-Hydroxybetulinic acid from Pulsatilla chinensis (Bunge) Regel synergizes the antitumor activities of doxorubicin in vitro and in vivo. J Ethnopharmacol. 2010 Apr 21;128(3):615-22.

23-羟基白桦酸物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 585.8±25.0 °C at 760 mmHg
• 熔点: 305 °C
• 分子式: C₃₀H₄₈O₄
• 分子量: 472.700
• 闪点: 322.1±19.7 °C
• 精确质量: 472.355255
• PSA: 77.76000
• LogP: 7.29
• InChIKey: HXWLKAXCQLXHML-FSWYEITMSA-N
• SMILES: C=C(C)C1CCC2(C(=O)O)CCC3(C)C(CCC4C5(C)CCC(O)C(C)(CO)C5CCC43C)C12
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 0.0±3.7 mmHg at 25°C
• 折射率: 1.543
• 储存条件: -20°C;存放于惰性气体之中;避免光,湿气 (分解),加热

23-羟基白桦酸靶点实验

查看更多实验

实验名称：Antitumor activity against human H22 cells xenografted in ICR mouse assessed as tumor... 来源：ChEMBL 靶标：H22 External Id：CHEMBL3374168

实验名称：Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：HeLa External Id：CHEMBL3374170

实验名称：Antiproliferative activity against mouse B16 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：B16 External Id：CHEMBL3374169

实验名称：Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3374172

实验名称：Antiproliferative activity against human SF763 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3374171

实验名称：Inhibition of CES1A1 in human liver microsomes using D-luciferin methyl ester as subs... 来源：ChEMBL 靶标：Liver carboxylesterase 1 External Id：CHEMBL4702261

实验名称：Inhibition of CES2A1 in human liver microsomes using D-luciferin methyl ester as subs... 来源：ChEMBL 靶标：Cocaine esterase External Id：CHEMBL4702260

实验名称：Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3374173

实验名称：Antitumor activity against mouse B16 cells allografted in ICR mouse assessed as tumor... 来源：ChEMBL 靶标：B16 External Id：CHEMBL3377229

实验名称：Inhibition of rabbit muscle glycogen phosphorylase A assessed as phosphate release fr... 来源：ChEMBL 靶标：Glycogen phosphorylase, muscle form External Id：CHEMBL961425

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23-羟基白桦酸英文别名

• (3β,13α)-3,23-Dihydroxylup-20(29)-en-28-oic acid
• Anemosapogenin
• (3β)-3,23-Dihydroxylup-20(29)-en-28-oic acid
• 23-Hydroxybetulinic acid
• 3|A,23-Dihydroxylup-20(29)-en-28-oic acid
• 23-hydroxy butulinic acid
• 23-HBA