HMB-Val-Ser-Leu-VE

• 常用名: HMB-Val-Ser-Leu-VE
• 英文名: HMB-Val-Ser-Leu-VE
• CAS号: 862891-04-1
• 分子量: 505.60
• 密度: 1.2±0.1 g/cm3
• 沸点: 754.1±60.0 °C at 760 mmHg
• 分子式: C₂₆H₃₉N₃O₇
• 熔点: N/A
• 闪点: 409.8±32.9 °C

HMB-Val-Ser-Leu-VE用途

HMB-Val-Ser-Leu-VE 是一种 prototype vinyl ester 乙烯酯抑制剂。HMB-Val-Ser-Leu-VE 具有抑制胰蛋白酶样 (T-L) 蛋白酶体活性的IC50为 0.033 μM。

HMB-Val-Ser-Leu-VE名称

• 英文名: HMB-Val-Ser-Leu-VE

HMB-Val-Ser-Leu-VE生物活性

• 描述: HMB-Val-Ser-Leu-VE 是一种 prototype vinyl ester 乙烯酯抑制剂。HMB-Val-Ser-Leu-VE 具有抑制胰蛋白酶样 (T-L) 蛋白酶体活性的IC50为 0.033 μM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> Ser/Thr蛋白酶
  研究领域 >> 其他
• 靶点实验:

  IC50: prototype vinyl ester[1]

• 参考文献:

  [1]. Anna Baldisserotto, et al. C-terminal constrained phenylalanine as a pharmacophoric unit in peptide-based proteasome inhibitors. Eur J Med Chem. 2008 Jul;43(7):1403-11.

HMB-Val-Ser-Leu-VE物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 754.1±60.0 °C at 760 mmHg
• 分子式: C₂₆H₃₉N₃O₇
• 分子量: 505.60
• 闪点: 409.8±32.9 °C
• 精确质量: 505.278809
• PSA: 154.06000
• LogP: 4.16
• InChIKey: YQKMRGLFGXKLJC-VOSPOJDESA-N
• SMILES: CCOC(=O)C=CC(CC(C)C)NC(=O)C(CO)NC(=O)C(NC(=O)c1cccc(O)c1C)C(C)C
• 蒸汽压: 0.0±2.7 mmHg at 25°C
• 折射率: 1.539
• 储存条件: -20°C，密闭，干燥

HMB-Val-Ser-Leu-VE靶点实验

查看更多实验

实验名称：Half-life in culture medium (RPMI) in the presence of 10% foetal calf serum by incuba... 来源：ChEMBL 靶标：N/A External Id：CHEMBL851034

实验名称：Inhibition of post-acidic-like (PGPH) activity of the proteasome purified from lympho... 来源：ChEMBL 靶标：Proteasome External Id：CHEMBL830896

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：In vivo inhibition of chymotrypsin like 20S proteasome 来源：ChEMBL 靶标：N/A External Id：CHEMBL969913

实验名称：In vivo inhibition of trypsin like 20S proteasome 来源：ChEMBL 靶标：N/A External Id：CHEMBL969912

实验名称：Half life in human plasma after 360 mins 来源：ChEMBL 靶标：Plasma External Id：CHEMBL969915

实验名称：In vivo inhibition of caspase like 20S proteasome 来源：ChEMBL 靶标：N/A External Id：CHEMBL969914

实验名称：Inhibition of trypsin like 20S proteasome activity in lymphoblastoid cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL969909

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

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HMB-Val-Ser-Leu-VE英文别名

• N-(3-Hydroxy-2-methylbenzoyl)-L-valyl-N-[(2E,4S)-1-ethoxy-6-methyl-1-oxo-2-hepten-4-yl]-L-serinamide
• N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(2E,4S)-1-ethoxy-6-methyl-1-oxohept-2-en-4-yl]-L-serinamide