HMB-Val-Ser-Leu-VE

Modify Date: 2025-08-25 12:49:26

HMB-Val-Ser-Leu-VE Structure
HMB-Val-Ser-Leu-VE structure
Common Name HMB-Val-Ser-Leu-VE
CAS Number 862891-04-1 Molecular Weight 505.60
Density 1.2±0.1 g/cm3 Boiling Point 754.1±60.0 °C at 760 mmHg
Molecular Formula C26H39N3O7 Melting Point N/A
MSDS N/A Flash Point 409.8±32.9 °C

 Use of HMB-Val-Ser-Leu-VE


HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC50 of 0.033 μM[1].

 Names

Name HMB-Val-Ser-Leu-VE
Synonym More Synonyms

 HMB-Val-Ser-Leu-VE Biological Activity

Description HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC50 of 0.033 μM[1].
Related Catalog
Target

IC50: prototype vinyl ester[1]

References

[1]. Anna Baldisserotto, et al. C-terminal constrained phenylalanine as a pharmacophoric unit in peptide-based proteasome inhibitors. Eur J Med Chem. 2008 Jul;43(7):1403-11.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 754.1±60.0 °C at 760 mmHg
Molecular Formula C26H39N3O7
Molecular Weight 505.60
Flash Point 409.8±32.9 °C
Exact Mass 505.278809
PSA 154.06000
LogP 4.16
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.539
InChIKey YQKMRGLFGXKLJC-VOSPOJDESA-N
SMILES CCOC(=O)C=CC(CC(C)C)NC(=O)C(CO)NC(=O)C(NC(=O)c1cccc(O)c1C)C(C)C

 Synonyms

N-(3-Hydroxy-2-methylbenzoyl)-L-valyl-N-[(2E,4S)-1-ethoxy-6-methyl-1-oxo-2-hepten-4-yl]-L-serinamide
N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(2E,4S)-1-ethoxy-6-methyl-1-oxohept-2-en-4-yl]-L-serinamide
L-Serinamide, N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(1S,2E)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-buten-1-yl]-
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