多粘菌素B九肽

• 常用名: 多粘菌素B九肽
• 英文名: Polymyxin B nonapeptide
• CAS号: 86408-36-8
• 分子量: 963.13500
• 密度: 1.32g/cm3
• 沸点: 1456.2ºC at 760 mmHg
• 分子式: C₄₃H₇₄N₁₄O₁₁
• 熔点: N/A
• 闪点: 834.5ºC

多粘菌素B九肽用途

Polymyxin B nonapeptide 是一种阳离子环肽。Polymyxin B nonapeptide 是经酶裂解 Polymyxin B 而产生的衍生物,与 Polymyxin B 相比,Polymyxin B nonapeptide 毒性低,缺乏杀菌活性,仍具有破坏革兰氏阴性菌外膜的能力。

多粘菌素B九肽名称

• 中文名: 多粘菌素B九肽
• 英文名: (2S,3R)-2-amino-N-[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]-3-hydroxybutanamide

多粘菌素B九肽生物活性

• 描述: Polymyxin B nonapeptide 是一种阳离子环肽。Polymyxin B nonapeptide 是经酶裂解 Polymyxin B 而产生的衍生物,与 Polymyxin B 相比,Polymyxin B nonapeptide 毒性低,缺乏杀菌活性,仍具有破坏革兰氏阴性菌外膜的能力。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 多粘菌素B九肽,一种通过酶促加工从天然肽多粘菌素B衍生而来的阳离子环肽,能够通过与细菌脂多糖(LPS)结合,增加革兰氏阴性菌外膜对疏水性抗生素的渗透性[1] ]。
• 参考文献:

  [1]. Tsubery H, et al. Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria. J Med Chem. 2000 Aug 10;43(16):3085-92.

  [2]. Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7.

多粘菌素B九肽物理化学性质

• 密度: 1.32g/cm3
• 沸点: 1456.2ºC at 760 mmHg
• 分子式: C₄₃H₇₄N₁₄O₁₁
• 分子量: 963.13500
• 闪点: 834.5ºC
• 精确质量: 962.56600
• PSA: 463.87000
• LogP: 0.27100
• InChIKey: PYHYGIPVYYRJHU-UHFFFAOYSA-N
• SMILES: CC(C)CC1NC(=O)C(Cc2ccccc2)NC(=O)C(CCN)NC(=O)C(NC(=O)C(CCN)NC(=O)C(N)C(C)O)CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC1=O
• 折射率: 1.607
• 储存条件: 2-8℃

多粘菌素B九肽靶点实验

查看更多实验

实验名称：Toxicity in mouse 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1114504

实验名称：Displacement of dansyl-PMB from LPS by isothermal titration calorimetry 来源：ChEMBL 靶标：Lipopolysaccharide (LPS) External Id：CHEMBL1114508

实验名称：Antibacterial activity against Staphylococcus aureus ATCC 29213 by CLSI broth microdi... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL1059660

实验名称：Toxicity index, ratio of test compound TC50 to polymyxin B TC50 for cytotoxicity agai... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5153222

实验名称：Antibacterial activity against LPS-deffective Escherichia coli OC2530 by CLSI broth m... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL1059659

实验名称：Antimicrobial activity against Escherichia coli assessed as relative sensitizing acti... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL1114514

实验名称：Antibacterial activity against Escherichia coli NovaBlue by CLSI broth microdilution ... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL1059671

实验名称：Antimicrobial activity against Escherichia coli IH3080 assessed as zone of inhibition... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL1637483

实验名称：Antimicrobial activity against Escherichia coli IH3080 assessed as zone of inhibition... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL1637484

实验名称：Antimicrobial activity against Acinetobacter baumannii ATCC 19606 assessed as zone of... 来源：ChEMBL 靶标：Acinetobacter baumannii External Id：CHEMBL1637485

共57条，当前第1页，共6页

1

2

3

4

5

多粘菌素B九肽英文别名

• triisopropylsilanthiol
• H-Thr-2,4-diaminobutyryl-cyclo[2,4-diaminobutyryl-2,4-diaminobutyryl-D-Phe-Leu-2,4-diaminobutyryl-2,4-diaminobutyryl-Thr]
• polymyxin B nonapeptide
• HSSi(i-Pr)3
• TRI-ISOPROPYLSILANETHIOL
• H-Thr-Dab-cyclic-(Dab-Dab-D-Phe-Leu-Dab-Dab-Thr)
• polymixin B nonapeptide
• T-X-cyclo[X-X-DF-L-X-X-T]