吡罗昔康肉桂酸酯

• 常用名: 吡罗昔康肉桂酸酯
• 英文名: SPA-S 510
• CAS号: 87234-24-0
• 分子量: 461.490
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₄H₁₉N₃O₅S
• 熔点: 261ºC
• 闪点: N/A

吡罗昔康肉桂酸酯用途

肉桂酸吡罗昔康(Cinnoxicam)是一种环氧合酶(COX)抑制剂,具有抗炎活性。肉桂酸吡罗昔康在胃部条件下是稳定的,可用于炎性退行性骨关节疾病、风湿性疾病和精索静脉曲张(VC)相关的弱精子症研究[1][2][4]。

吡罗昔康肉桂酸酯名称

• 中文名: 辛诺昔康
• 英文名: [2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1λ6,2-benzothiazin-4-yl] (E)-3-phenylprop-2-enoate
• 中文别名: 吡罗昔康肉桂酸酯

吡罗昔康肉桂酸酯生物活性

• 描述: 肉桂酸吡罗昔康(Cinnoxicam)是一种环氧合酶(COX)抑制剂,具有抗炎活性。肉桂酸吡罗昔康在胃部条件下是稳定的,可用于炎性退行性骨关节疾病、风湿性疾病和精索静脉曲张(VC)相关的弱精子症研究[1][2][4]。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> COX
• 体内研究: 肉桂酸吡罗昔康可减轻大鼠后爪蛋清引起的足底水肿[3]。

吡罗昔康肉桂酸酯物理化学性质

• 密度: 1.5±0.1 g/cm3
• 熔点: 261ºC
• 分子式: C₂₄H₁₉N₃O₅S
• 分子量: 461.490
• 精确质量: 461.104553
• PSA: 114.05000
• LogP: 3.96
• InChIKey: GPUVGQIASQNZET-CCEZHUSRSA-N
• SMILES: CN1C(C(=O)Nc2ccccn2)=C(OC(=O)C=Cc2ccccc2)c2ccccc2S1(=O)=O
• 折射率: 1.697

吡罗昔康肉桂酸酯靶点实验

查看更多实验

实验名称：Binding affinity towards human ADRA2A in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Alpha-2A adrenergic receptor External Id：CHEMBL5291736

实验名称：Binding affinity towards human GABRA1 in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit gamma-2 External Id：CHEMBL5291799

实验名称：Binding affinity towards human PGR in an in vitro assay with cellular components meas... 来源：ChEMBL 靶标：Progesterone receptor External Id：CHEMBL5291863

实验名称：Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluor... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5291731

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291792

实验名称：Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with ... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL5291728

实验名称：Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay m... 来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A External Id：CHEMBL5291856

实验名称：Binding affinity towards human OPRM1 in an in vitro assay with cellular components me... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL5291855

实验名称：Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5291730

实验名称：Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas... 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL5291794

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吡罗昔康肉桂酸酯英文别名

• 3-Phenyl-2-propenoic Acid 2-Methyl-3-((2-pyridinylamino)carbonyl)-2H-1,2-benzothiazin-4-yl Ester S,S-Dioxide
• 2-Methyl-1,1-dioxido-3-(2-pyridinylcarbamoyl)-2H-1,2-benzothiazin-4-yl (2E)-3-phenylacrylate
• SPA-S-51O
• SPA-S-510
• SPA-S 510
• 4-Hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide Cinnamate (Ester)
• Cinnoxicam
• Piroxicam cinnamate
• Piroxicam cinnamic acid ester
• 2-methyl-1,1-dioxido-3-(pyridin-2-ylcarbamoyl)-2H-1,2-benzothiazin-4-yl (2E)-3-phenylprop-2-enoate
• Piroxicam cinnamate (USAN)
• Sinartrol