Psncbam-1

• 常用名: Psncbam-1
• 英文名: PSNCBAM-1
• CAS号: 877202-74-9
• 分子量: 392.88100
• 密度: N/A
• 沸点: 521.5±50.0 °C(Predicted)
• 分子式: C₂₂H₂₁ClN₄O
• 熔点: N/A
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

Psncbam-1用途

PSNCBAM-1是一种选择性CB1受体变构拮抗剂,其EC50为0.1μM。PSNCBAM-1可用于肥胖研究[1]。

Psncbam-1名称

• 中文名: Psncbam-1
• 英文名: Urea, N-(4-chlorophenyl)-N'-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]

Psncbam-1生物活性

• 描述: PSNCBAM-1是一种选择性CB1受体变构拮抗剂,其EC50为0.1μM。PSNCBAM-1可用于肥胖研究[1]。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
• 靶点实验:

  hCB1-R:0.1 μM (EC50)

• 参考文献:

  [1]. Horswill JG, et al. PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br J Pharmacol. 2007 Nov;152(5):805-14.

Psncbam-1物理化学性质

• 沸点: 521.5±50.0 °C(Predicted)
• 分子式: C₂₂H₂₁ClN₄O
• 分子量: 392.88100
• 精确质量: 392.14000
• PSA: 57.26000
• LogP: 5.85720
• InChIKey: HDAYFSFWIPRJSO-UHFFFAOYSA-N
• SMILES: O=C(Nc1ccc(Cl)cc1)Nc1cccc(-c2cccc(N3CCCC3)n2)c1
• 储存条件: 2-8°C

Psncbam-1安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H319
• 警示性声明: P305 + P351 + P338
• 危险品运输编码: NONH for all modes of transport

Psncbam-1靶点实验

查看更多实验

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Negative allosteric modulator activity at human CB1R expressed in CHO-K1 cells assess... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL3760354

实验名称：Negative allosteric modulator activity at human CB1R expressed in CHO-K1 cells assess... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL3760353

实验名称：Negative allosteric modulator activity at human CB1R expressed in CHO-K1 cells assess... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL3760352

实验名称：Allosteric modulation of CB1 receptor (unknown origin) assessed as inhibition of CP55... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL4329660

实验名称：Agonist activity at CB1 receptor (unknown origin) relative to CP55940 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL4329659

实验名称：Allosteric modulation of CB1 receptor (unknown origin) assessed as inhibition of calc... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL4329658

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Negative allosteric modulator activity at human CB1R expressed in CHO-K1 cells assess... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL3760355

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Psncbam-1英文别名

• PSNCBAM 1
• 1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]urea