INF 4E,半胱天冬酶-1和NLRP3炎性体抑制剂

• 常用名: INF 4E,半胱天冬酶-1和NLRP3炎性体抑制剂
• 英文名: INF 4E
• CAS号: 88039-46-7
• 分子量: 240.68300
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₁₃ClO₃
• 熔点: N/A
• 闪点: N/A

INF 4E,半胱天冬酶-1和NLRP3炎性体抑制剂用途

INF4E是一种有效的NLRP3炎症体抑制剂。INF4E抑制caspase-1和NLRP3 ATP酶活性。INF4E对IR引起的心肌损伤和功能障碍具有保护作用[1][2]。

INF 4E,半胱天冬酶-1和NLRP3炎性体抑制剂名称

• 中文名: INF 4E,半胱天冬酶-1和NLRP3炎性体抑制剂
• 英文名: ethyl 2-((2-chlorophenyl)(hydroxy)methyl)acrylate

INF 4E,半胱天冬酶-1和NLRP3炎性体抑制剂生物活性

• 描述: INF4E是一种有效的NLRP3炎症体抑制剂。INF4E抑制caspase-1和NLRP3 ATP酶活性。INF4E对IR引起的心肌损伤和功能障碍具有保护作用[1][2]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> NOD样受体(NLR)
  研究领域 >> 炎症/免疫
• 体外研究: INF4E(化合物9)以时间和浓度依赖性方式预防ATP和尼日利亚霉素触发的人类THP-1细胞热下垂[3]。
• 体内研究: INF4E显著减少梗死范围和乳酸脱氢酶的释放,并改善缺血后左心室压力[1]。INF4E以时间依赖性方式减弱心肌IR(缺血/再灌注)诱导的NLRP3炎症复合物的形成[1]。
• 参考文献:

  [1]. Shi Y, et al. NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages. Int Immunopharmacol. 2021 Mar;92:107358.

  [2]. Mezzaroma E,et al. NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases. Molecules. 2021 Feb 12;26(4):976.

  [3]. occo M, et al. Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J Med Chem. 2014 Dec 26;57(24):10366-82.

INF 4E,半胱天冬酶-1和NLRP3炎性体抑制剂物理化学性质

• 分子式: C₁₂H₁₃ClO₃
• 分子量: 240.68300
• 精确质量: 240.05500
• PSA: 46.53000
• LogP: 2.49270
• InChIKey: BSRPDXCMAOIUOO-UHFFFAOYSA-N
• SMILES: C=C(C(=O)OCC)C(O)c1ccccc1Cl
• 储存条件: -20°C

INF 4E,半胱天冬酶-1和NLRP3炎性体抑制剂靶点实验

查看更多实验

实验名称：Antipyroptotic activity in PMA-differentiated and LPS-primed human THP1 cells assesse... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3390766

实验名称：Antipyroptotic activity in PMA-differentiated and LPS-primed human THP1 cells assesse... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3390768

实验名称：Cytotoxicity against human HK2 cells assessed as cell viability after 72 hrs by MTT a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3390767

实验名称：Antimicrobial activity against Corynebacterium diphtheriae 来源：ChEMBL 靶标：Corynebacterium diphtheriae External Id：CHEMBL2049886

实验名称：Antimicrobial activity against Klebsiella pneumoniae 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL2049887

实验名称：Antimicrobial activity against Staphylococcus aureus 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL2049885

实验名称：Larvicidal activity against fourth instar Aedes aegypti larvae assessed as mortality ... 来源：ChEMBL 靶标：Aedes aegypti External Id：CHEMBL5327288

实验名称：Larvicidal activity against fourth instar Aedes aegypti larvae assessed as lethal con... 来源：ChEMBL 靶标：Aedes aegypti External Id：CHEMBL5327289

实验名称：Binding affinity to human serum albumin after 5 mins by RP-UHPLC analysis 来源：ChEMBL 靶标：Albumin External Id：CHEMBL4015417

实验名称：Cysteamine reactivity of the compound in PBS assessed as second order rate constant f... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4015418

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INF 4E,半胱天冬酶-1和NLRP3炎性体抑制剂英文别名

• 2-[hydroxy(2-chlorophenyl)methyl]acrylic acid ethyl ester
• 2-[(2-Chloro-phenyl)-hydroxy-methyl]-acrylic acid ethyl ester