4-Deoxypyridoxine 5'-phosphate

• 常用名: 4-Deoxypyridoxine 5'-phosphate
• 英文名: 4-Deoxypyridoxine 5'-phosphate
• CAS号: 883-84-1
• 分子量: 233.15800
• 密度: 1.499g/cm3
• 沸点: 567.6ºC at 760 mmHg
• 分子式: C₈H₁₂NO₅P
• 熔点: N/A
• 闪点: 297.1ºC

4-Deoxypyridoxine 5'-phosphate用途

4-Deoxypyridoxine 5'-phosphate 是一种 Pyridoxal 5'-phosphate 的类似物,也是一种鞘氨醇1-磷酸酯 (S1P) 抑制剂。4-Deoxypyridoxine 5'-phosphate 抑制鸟氨酸脱羧酶 (ornithine decarboxylase) 活性,Ki 为 60 μM。4-Deoxypyridoxine 5'-phosphate 是 Pyridoxal 5'-phosphate 激活谷氨酸脱羧酶 (glutamate apodecarboxylase) 的竞争性抑制剂 (Ki 为 0.27 μM),并强烈抑制谷氨酸依赖于谷氨酸脱羧酶的标记。

4-Deoxypyridoxine 5'-phosphate名称

• 英文名: (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate

4-Deoxypyridoxine 5'-phosphate生物活性

• 描述: 4-Deoxypyridoxine 5'-phosphate 是一种 Pyridoxal 5'-phosphate 的类似物,也是一种鞘氨醇1-磷酸酯 (S1P) 抑制剂。4-Deoxypyridoxine 5'-phosphate 抑制鸟氨酸脱羧酶 (ornithine decarboxylase) 活性,Ki 为 60 μM。4-Deoxypyridoxine 5'-phosphate 是 Pyridoxal 5'-phosphate 激活谷氨酸脱羧酶 (glutamate apodecarboxylase) 的竞争性抑制剂 (Ki 为 0.27 μM),并强烈抑制谷氨酸依赖于谷氨酸脱羧酶的标记。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> LPL受体
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 代谢疾病
• 靶点实验:

  Sphingosine 1-phosphate (S1P)[1] Ornithine decarboxylase[2] Glutamate apodecarboxylase[3]

• 参考文献:

  [1]. Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216.

  [2]. M J Connor, et al. Epidermal Pyridoxal 5'-phosphate Depletion, Inhibition of DNA Synthesis, and Inhibition of the Expression of Ornithine Decarboxylase Activity by the Vitamin B-6 Antagonist 4'-deoxypyridoxine. J Invest Dermatol. 1983 Aug;81(2):136-9.

  [3]. D L Martin, et al. Glutamate-dependent Active-Site Labeling of Brain Glutamate Decarboxylase. J Neurochem. 1990 Aug;55(2):524-32.

4-Deoxypyridoxine 5'-phosphate物理化学性质

• 密度: 1.499g/cm3
• 沸点: 567.6ºC at 760 mmHg
• 分子式: C₈H₁₂NO₅P
• 分子量: 233.15800
• 闪点: 297.1ºC
• 精确质量: 233.04500
• PSA: 109.69000
• LogP: 1.01330
• InChIKey: RBCOYOYDYNXAFA-UHFFFAOYSA-N
• SMILES: Cc1ncc(COP(=O)(O)O)c(C)c1O
• 折射率: 1.59
• 储存条件: 2-8°C，干燥，密封

4-Deoxypyridoxine 5'-phosphate安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2933399090

4-Deoxypyridoxine 5'-phosphate海关

• 海关编码: 2933399090
• 中文概述: 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-Deoxypyridoxine 5'-phosphate靶点实验

查看更多实验

实验名称：Dual reporter qHTS for antagonist of Pregnane X Receptor (hPXR) against the NCATS DSH... 来源：NCGC External Id：DSHEA-v1-PXR-antagonist-CTF

实验名称：Dual reporter qHTS for antagonist of Pregnane X Receptor (hPXR) against the NCATS DSH... 来源：NCGC External Id：DSHEA-v1-PXR-antagonist-ONEGlo

实验名称：Assays to identify small molecules inhibitory for eIF4E expression 来源：13133 靶标：N/A External Id：20160513eIF4E

实验名称：HepG2 viability counterscreen (readout 2: ATP content) against the NCATS DSHEA and TC... 来源：NCGC 靶标：N/A External Id：DSHEA-v1-HepG2-viability-CTG-ATP

实验名称：Experimentally measured binding affinity data (Ki) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Ki for protein-ligand complexes

实验名称：Dual reporter qHTS for agonist of Pregnane X Receptor (hPXR) against the NCATS DSHEA ... 来源：NCGC External Id：DSHEA-v1-PXR-agonist-ONEGlo

实验名称：Dual reporter qHTS for agonist of Pregnane X Receptor (hPXR) against the NCATS DSHEA ... 来源：NCGC External Id：DSHEA-v1-PXR-agonist-CTF

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：KB-8-5-11 P-gp reporter qHTS against the NCATS DSHEA and TCM libraries 来源：NCGC 靶标：N/A External Id：DSHEA-v1-KB-8-5-11-CTG

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4-Deoxypyridoxine 5'-phosphate英文别名

• 1ggn
• vitamin B-6
• PLR
• Deoxypyridoxine-P
• 4-Deoxypyridoxine 5'-phosphate
• 4-Desoxy-pyridoxol-phosphat
• 4-Deoxypyridoxin-5'-phosphat