CAY10502

更新时间：2025-08-25 20:32:45

CAY10502结构式	常用名	CAY10502	英文名	CAY10502
	CAS号	888320-29-4	分子量	523.617
	密度	1.2±0.1 g/cm3	沸点	693.6±55.0 °C at 760 mmHg
	分子式	C₃₀H₃₇NO₇	熔点	N/A
	MSDS	N/A	闪点	373.3±31.5 °C

CAY10502用途

CAY10502是一种有效的钙依赖性胞浆磷脂酶A2α(cPLA2α)抑制剂,分离酶的IC50为4.3nm。CAY10502可用于视网膜病变和炎症性疾病的研究[1][2][3]。

英文名	cay10502
英文别名	更多

描述	CAY10502是一种有效的钙依赖性胞浆磷脂酶A2α(cPLA2α)抑制剂,分离酶的IC50为4.3nm。CAY10502可用于视网膜病变和炎症性疾病的研究[1][2][3]。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 磷脂研究领域 >> 炎症/免疫
靶点实验	cPLA2α:4.3 nM (IC50)
体外研究	CAY10502抑制人血小板中由A23187和TPA刺激的cPLA2R介导的花生四烯酸释放,IC50分别为0.57和0.0009μM[1]。CAY10502(5,20,50纳米；12小时；müller细胞)抑制常氧和缺氧诱导的前列腺素E2(PGE2)和VEGF生成[2]。CAY10502(0.1-100纳米；24小时)抑制VEGF诱导的大鼠视网膜微血管内皮细胞(RRMEC)增殖[2]。CAY10502(10μM)抑制花生四烯酸(AA)从磷脂池中释放,消除极低频电磁场(ELF-EMF；1h)诱导的AA增加和Cav3的ELF-EMF抑制作用。2个频道[3]。细胞增殖试验[2]细胞系：RRMEC浓度：0.1-100 nM培养时间：24小时结果：与单独使用VEGF处理的培养物相比,CAY10502(35,50 nM)显示VEGF诱导的增殖显著减少(分别为64.3%和84.1%)。
体内研究	注射CAY10502(2.5,25,100 nM；5μL)的眼睛在大鼠氧诱导视网膜病变(OIR)中显示出对视网膜新生血管(NV)的剂量依赖性抑制[2]。动物模型：OIR和室内空气(RA)Sprague-Dawley大鼠[2]剂量：2.5,25,100nm；5μL给药：玻璃体内注射结果：与溶媒治疗相比,注射100 nM CAY10502可使NV降低53.1%。
参考文献	[1]. Pohjala L L, et al. Interference by bovine serum albumin in PED6 based phospholipase A2 screening assays[J]. Die Pharmazie, 2012. [2]. Barnett JM, et al. Role of cytosolic phospholipase A(2) in retinal neovascularization. Invest Ophthalmol Vis Sci. 2010;51(2):1136-1142. [3]. Cui Y, et al. Exposure to extremely low-frequency electromagnetic fields inhibits T-type calcium channels via AA/LTE4 signaling pathway. Cell Calcium. 2014 Jan;55(1):48-58.

密度	1.2±0.1 g/cm3
沸点	693.6±55.0 °C at 760 mmHg
分子式	C₃₀H₃₇NO₇
分子量	523.617
闪点	373.3±31.5 °C
精确质量	523.257019
PSA	104.06000
LogP	7.96
InChIKey	NXDZVUAKVFVDSL-UHFFFAOYSA-N
SMILES	CCCCCCCCCCOc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(C(=O)O)ccc32)cc1
蒸汽压	0.0±2.3 mmHg at 25°C
折射率	1.559
储存条件	-20°C，密闭，干燥

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来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：HCMV UL50
External Id：HMS1262

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来源：ChEMBL
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External Id：CHEMBL863829

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靶标：N/A
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External Id：CHEMBL863831

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来源：The Scripps Research Institute Molecular Screening Center
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靶标：Cellular tumor antigen p53
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External Id：VANDERBILT_HTS_GIRK2_MPD

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1H-Indole-3,5-dicarboxylic acid, 1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-, 3-methyl ester

1-{3-[4-(Decyloxy)phenoxy]-2-oxopropyl}-3-(methoxycarbonyl)-1H-indole-5-carboxylic acid