2-(9-氯-1H-菲酚[9,10-d]咪唑-2-基)-1,3-苯二甲腈

• 常用名: 2-(9-氯-1H-菲酚[9,10-d]咪唑-2-基)-1,3-苯二甲腈
• 英文名: MF63
• CAS号: 892549-43-8
• 分子量: 378.81300
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₁₁ClN₄
• 熔点: N/A
• 闪点: N/A

用途

MF63是mPGES-1抑制剂，对猪mPGES-1和人mPGES-1的IC50分别为0.9 nM和1.3 nM。

名称

• 中文名: 2-(9-氯-1H-菲酚[9,10-d]咪唑-2-基)-1,3-苯二甲腈
• 英文名: 2-(6-chloro-3H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile

生物活性

• 描述: MF63是mPGES-1抑制剂,对猪mPGES-1和人mPGES-1的IC50分别为0.9 nM和1.3 nM。
• 相关类别:
  信号通路 >> 免疫及炎症 >> PGE合成酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Xu D et al. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. J Pharmacol Exp Ther. 2008 Sep;326(3):754-6

  [2]. Coté B et al. Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6816-20.

  [3]. Baragatti B, Coceani F.,Dual, constrictor-to-dilator, response of the mouse ductus arteriosus to the microsomal prostaglandin E synthase-1 inhibitor, 2-(6-chloro-1H-phenanthro[9,10d]imidazole- 2-yl)isophthalonitrile.,Neonatology. 2011;100(2):139-46. Epub

  [4]. Giroux A, et al. Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.,Bioorg Med Chem Lett. 2009 Oct 15;19(20):5837-41. Epub 2009 Aug 28.

  [5]. Xu D, L,et al. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.,J Pharmacol Exp Ther. 2008 Sep;326(3):75

物理化学性质

• 分子式: C₂₃H₁₁ClN₄
• 分子量: 378.81300
• 精确质量: 378.06700
• PSA: 76.26000
• LogP: 5.93306
• 储存条件: 2-8℃

英文别名

• S1560_Selleck
• CS-0508
• QCR-11
• MF63