STF-118804

• 常用名: STF-118804
• 英文名: STF 118804
• CAS号: 894187-61-2
• 分子量: 461.533
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₅H₂₃N₃O₄S
• 熔点: N/A
• 闪点: N/A

STF-118804用途

STF-118804是烟酰胺磷酸核糖基转移酶Nampt高选择性抑制剂,细胞viability IC50小于10nM。

STF-118804名称

• 中文名: STF-118804
• 英文名: 4-[5-methyl-4-[(4-methylphenyl)sulfonylmethyl]-1,3-oxazol-2-yl]-N-(pyridin-3-ylmethyl)benzamide

STF-118804生物活性

• 描述: STF-118804是烟酰胺磷酸核糖基转移酶Nampt高选择性抑制剂,细胞viability IC50小于10nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> NAMPT
  研究领域 >> 癌症
• 参考文献:

  [1]. Matheny CJ, et al. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21;20(11):1352-63.

STF-118804物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₅H₂₃N₃O₄S
• 分子量: 461.533
• 精确质量: 461.140930
• PSA: 110.54000
• LogP: 3.08
• InChIKey: DLFCEZOMHBPDGI-UHFFFAOYSA-N
• SMILES: Cc1ccc(S(=O)(=O)Cc2nc(-c3ccc(C(=O)NCc4cccnc4)cc3)oc2C)cc1
• 外观性状: 粉末
• 折射率: 1.609
• 储存条件: -20℃

STF-118804安全信息

• 危险品运输编码: NONH for all modes of transport

STF-118804靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Induction of apoptosis in human KOPN8 cells assessed as late apoptotic cells level af... 来源：ChEMBL 靶标：KOPN-8 External Id：CHEMBL4423521

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Induction of apoptosis in human KOPN8 cells assessed as late apoptotic cells level af... 来源：ChEMBL 靶标：KOPN-8 External Id：CHEMBL4423522

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Cell cycle arrest in human KOPN8 cells assessed as increase in accumulation of cells ... 来源：ChEMBL 靶标：KOPN-8 External Id：CHEMBL4423511

实验名称：Permeability of compound at pH 7.4 assessed as drug retention by PAMPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL4423513

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STF-118804英文别名

• 4-(5-Methyl-4-{[(4-methylphenyl)sulfonyl]methyl}-1,3-oxazol-2-yl)-N-(3-pyridinylmethyl)benzamide
• STF-118804