GNE 9278

• 常用名: GNE 9278
• 英文名: GNE 9278
• CAS号: 901230-11-3
• 分子量: 429.536
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₁H₂₇N₅O₃S
• 熔点: N/A
• 闪点: N/A

GNE 9278用途

GNE-9278 is a potent and selective NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Mutation of a single residue near the Lurcher motif on GluN1 M3 can convert GNE-9278 modulation from positive to negative, and replacing three AMPAR pre-M1 residues with corresponding NMDAR residues can confer GNE-9278 sensitivity to AMPARs. Modulation by GNE-9278 is state-dependent and significantly alters extracellular domain pharmacology.

GNE 9278名称

• 英文名: 4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide

GNE 9278物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₁H₂₇N₅O₃S
• 分子量: 429.536
• 精确质量: 429.183472
• LogP: 5.24
• 折射率: 1.691

GNE 9278英文别名

• 4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide
• Benzenesulfonamide, 4-cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-