GNE 9278
Modify Date: 2024-01-19 19:53:42
GNE 9278 structure
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Common Name | GNE 9278 | ||
|---|---|---|---|---|
| CAS Number | 901230-11-3 | Molecular Weight | 429.536 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H27N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GNE 9278GNE-9278 is a potent and selective NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Mutation of a single residue near the Lurcher motif on GluN1 M3 can convert GNE-9278 modulation from positive to negative, and replacing three AMPAR pre-M1 residues with corresponding NMDAR residues can confer GNE-9278 sensitivity to AMPARs. Modulation by GNE-9278 is state-dependent and significantly alters extracellular domain pharmacology. |
| Name | 4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide |
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| Synonym | More Synonyms |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C21H27N5O3S |
| Molecular Weight | 429.536 |
| Exact Mass | 429.183472 |
| LogP | 5.24 |
| Index of Refraction | 1.691 |
| 4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide |
| Benzenesulfonamide, 4-cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)- |