7-木糖基紫杉醇

• 常用名: 7-木糖基紫杉醇
• 英文名: 7-Xylosyltaxol
• CAS号: 90332-66-4
• 分子量: 986.021
• 密度: 1.5±0.1 g/cm3
• 沸点: 1062.3±65.0 °C at 760 mmHg
• 分子式: C₅₂H₅₉NO₁₈
• 熔点: N/A
• 闪点: 596.3±34.3 °C

7-木糖基紫杉醇用途

7-xylosyltaxol(Taxol-7-xyloside)是紫杉醇衍生物。

7-木糖基紫杉醇名称

• 中文名: 7-木糖基-紫杉醇
• 英文名: (2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate
• 中文别名: 7-木糖基紫杉醇

7-木糖基紫杉醇生物活性

• 描述: 7-xylosyltaxol(Taxol-7-xyloside)是紫杉醇衍生物。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  天然产物 >> 萜类化合物和糖苷
  研究领域 >> 癌症
• 参考文献:

  [1]. Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in cultivated and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7.

  [2]. Chao Z, Tan M, Paudel MK, et al. Development of an indirect competitive enzyme-linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel. J Nat Med. 2012 Sep 25.

  [3]. Park SJ, Wu CH, Gordon JD, et al. Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 2004 Dec 3;279(49):51057-67. Epub 2004 Sep 27.

  [4]. Rao S, He L, Chakravarty S, et al. Characterization of the Taxol binding site on the microtubule. Identification of Arg(282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol. J Biol Chem. 1999 Dec 31;274(53):37990-4.

  [5]. Paclitaxel

7-木糖基紫杉醇物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 1062.3±65.0 °C at 760 mmHg
• 分子式: C₅₂H₅₉NO₁₈
• 分子量: 986.021
• 闪点: 596.3±34.3 °C
• 精确质量: 985.373230
• LogP: 7.81
• InChIKey: ZVEGOBHUZTXSFK-TZIKQHFSSA-N
• SMILES: CC(=O)OC1C(=O)C2(C)C(OC3OCC(O)C(O)C3O)CC3OCC3(OC(C)=O)C2C(OC(=O)c2ccccc2)C2(O)CC(OC(=O)C(O)C(NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.646
• 储存条件: 2-8℃

7-木糖基紫杉醇靶点实验

查看更多实验

实验名称：Antiproliferative activity against human A549 cells assessed as growth inhibition aft... 来源：ChEMBL 靶标：A549 External Id：CHEMBL3399186

实验名称：Antiproliferative activity against human HepG2 cells assessed as growth inhibition af... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL3399189

实验名称：Antiproliferative activity against human A2780 cells assessed as growth inhibition af... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL3399190

实验名称：Antiproliferative activity against human SW480 cells assessed as growth inhibition af... 来源：ChEMBL 靶标：SW480 External Id：CHEMBL3399187

实验名称：Antiproliferative activity against human MCF7 cells assessed as growth inhibition aft... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL3399188

实验名称：Antiproliferative activity against human HCT8/VCT cells assessed as growth inhibition... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3399193

实验名称：Antiproliferative activity against human A549/CDDP cells assessed as growth inhibitio... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3399194

实验名称：Antiproliferative activity against human A2780/TAX cells assessed as growth inhibitio... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3399191

实验名称：Antiproliferative activity against human HCT8 cells assessed as growth inhibition aft... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3399192

实验名称：Antiproliferative activity against human MCF7/DX cells assessed as growth inhibition ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3399195

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7-木糖基紫杉醇英文别名

• (2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate
• (2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate
• 7-Xylosyltaxol