替米沙坦酰胺

• 常用名: 替米沙坦酰胺
• 英文名: Telmisartan Amide
• CAS号: 915124-86-6
• 分子量: 513.63
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₃H₃₁N₅O
• 熔点: N/A
• 闪点: N/A

替米沙坦酰胺用途

PPARγ激动剂5(化合物1)是一种有效的选择性PPARγ激动剂。PPARγ激动剂5具有研究癌症疾病的潜力【1】。

替米沙坦酰胺名称

• 中文名: 替米沙坦酰胺
• 英文名: 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzamide
• 中文别名: 替米沙坦杂质F

替米沙坦酰胺生物活性

• 描述: PPARγ激动剂5(化合物1)是一种有效的选择性PPARγ激动剂。PPARγ激动剂5具有研究癌症疾病的潜力【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> PPAR
• 参考文献:

  [1]. Schoepf AM, et al. Identification and development of non-cytotoxic cell death modulators: Impact of sartans and derivatives on PPARγ activation and on growth of imatinib-resistant chronic myelogenous leukemia cells. Eur J Med Chem. 2020 Jun 1;195:112258.

替米沙坦酰胺物理化学性质

• 分子式: C₃₃H₃₁N₅O
• 分子量: 513.63
• 精确质量: 513.25300
• PSA: 79.72000
• LogP: 7.54930
• InChIKey: YAIWQMXHIQDCFT-UHFFFAOYSA-N
• SMILES: CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(N)=O)cc1
• 储存条件: 2-8℃

替米沙坦酰胺靶点实验

查看更多实验

实验名称：Agonist activity at human PPARgammaDEF receptor expressed in african green monkey COS... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL4768834

实验名称：Agonist activity at human PPARgammaDEF receptor expressed in african green monkey COS... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL4768835

实验名称：Induction of cell sensitization to imatinib in imatinib-resistant human K562 cells as... 来源：ChEMBL 靶标：K562 External Id：CHEMBL4815955

实验名称：Cytotoxicity against African green monkey COS7 cells assessed as effect on metabolic ... 来源：ChEMBL 靶标：COS-7 External Id：CHEMBL4768836

实验名称：Cytotoxicity against African green monkey COS7 cells assessed as effect on metabolic ... 来源：ChEMBL 靶标：COS-7 External Id：CHEMBL4768837

实验名称：Cytotoxicity against human HS5 cells assessed as cell death at 10 uM measured after 7... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4768843

实验名称：Modulation of cell death in imatinib-resistant human K562 cells assessed by increase ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4768840

实验名称：Modulation of cell death in imatinib-resistant human K562 cells assessed by increase ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4768841

实验名称：Induction of cell sensitization to imatinib in imatinib-resistant human K562 cells as... 来源：ChEMBL 靶标：K562 External Id：CHEMBL4815949

实验名称：Inhibition of STAT5 in imatinib-resistant human K562 cells assessed as effect on STAT... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 5A External Id：CHEMBL4768844

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替米沙坦酰胺英文别名

• Telmisartan Amide
• carboxamidotelmisartan
• UNII-0C9IQ6NHUX
• Telmisartan Impurity 6