CAY10575

• 常用名: CAY10575
• 英文名: CAY10575
• CAS号: 916985-21-2
• 分子量: 487.549
• 密度: 1.5±0.1 g/cm3
• 沸点: 735.4±70.0 °C at 760 mmHg
• 分子式: C₂₂H₂₁N₃O₆S₂
• 熔点: N/A
• 闪点: 398.5±35.7 °C

CAY10575用途

IKK2-IN-3(化合物8)是一种IKK2抑制剂,IC50为0.075μM[1]。

CAY10575名称

• 英文名: 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(4-methylsulfonylphenyl)methoxy]thiophene-2-carboxamide

CAY10575生物活性

• 描述: IKK2-IN-3(化合物8)是一种IKK2抑制剂,IC50为0.075μM[1]。
• 相关类别:
  信号通路 >> NF-κB信号通路 >> IKK
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
• 靶点实验:

  IKK2:0.075 μM (IC50)

• 参考文献:

  [1]. Xie HZ, et al. Pharmacophore modeling and hybrid virtual screening for the discovery of novel IκB kinase 2 (IKK2) inhibitors. J Biomol Struct Dyn. 2011 Aug;29(1):165-79.

CAY10575物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 735.4±70.0 °C at 760 mmHg
• 分子式: C₂₂H₂₁N₃O₆S₂
• 分子量: 487.549
• 闪点: 398.5±35.7 °C
• 精确质量: 487.087189
• PSA: 159.36000
• LogP: 1.74
• InChIKey: YYZTVTZCYVZGRB-UHFFFAOYSA-N
• SMILES: COc1cc2ncn(-c3cc(OCc4ccc(S(C)(=O)=O)cc4)c(C(N)=O)s3)c2cc1OC
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.671
• 储存条件: -20°C，密闭，干燥

CAY10575靶点实验

查看更多实验

实验名称：Scintillation Proximity Assay (SPA) from Article 10.1016/j.bmcl.2008.11.041: "Discove... 来源：BindingDB 靶标：N/A External Id：BindingDB_3112_1

实验名称：Antiproliferative activity against human HCT116 cells after 3 days by methylene blue ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL941578

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Inhibition of PLK1 expressed in baculovirus-infected Trichoplusia-ni cells by scintil... 来源：ChEMBL 靶标：Serine/threonine-protein kinase PLK1 External Id：CHEMBL941563

实验名称：Inhibition of human recombinant IKKepsilon by TR-FRET assay 来源：ChEMBL 靶标：Inhibitor of nuclear factor kappa-B kinase subunit epsilon External Id：CHEMBL911347

实验名称：Inhibition of IKK-beta 来源：ChEMBL 靶标：Inhibitor of nuclear factor kappa-B kinase subunit beta External Id：CHEMBL911348

实验名称：Inhibition of PLK1 来源：ChEMBL 靶标：Serine/threonine-protein kinase PLK1 External Id：CHEMBL911349

实验名称：Scintillation Proximity Assay (SPA) from Article 10.1016/j.bmcl.2006.09.018: "5-(1H-B... 来源：BindingDB 靶标：N/A External Id：BindingDB_3059_2

实验名称：IKK Kinase Inhibition Assay from Article 10.1016/j.bmcl.2006.09.018: "5-(1H-Benzimida... 来源：BindingDB 靶标：N/A External Id：BindingDB_3059_1

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CAY10575英文别名

• 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[4-(methylsulfonyl)benzyl]oxy}-2-thiophenecarboxamide
• HMS3229L15
• 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[4-(methylsulfonyl)benzyl]oxy}thiophene-2-carboxamide
• benzimidazole-thiophene carboxamide,2