CB2 receptor agonist 3

• 常用名: CB2 receptor agonist 3
• 英文名: CB2 receptor agonist 3
• CAS号: 919077-81-9
• 分子量: 440.365
• 密度: 1.4±0.1 g/cm3
• 沸点: 632.9±55.0 °C at 760 mmHg
• 分子式: C₂₄H₂₃Cl₂N₃O
• 熔点: N/A
• 闪点: 336.6±31.5 °C

CB2 receptor agonist 3用途

CB2受体激动剂3是一种稳健和选择性的CB2大麻素激动剂,CB2和CB1的Kis分别为7.6和900 nM。CB2受体激动剂3显著增加HL-60细胞中P-ERK 1/2的表达[1]。

CB2 receptor agonist 3名称

• 英文名: N-cyclohexyl-1-(2,4-dichlorophenyl)-6-methyl-4H-indeno[1,2-c]pyrazole-3-carboxamide

CB2 receptor agonist 3生物活性

• 描述: CB2受体激动剂3是一种稳健和选择性的CB2大麻素激动剂,CB2和CB1的Kis分别为7.6和900 nM。CB2受体激动剂3显著增加HL-60细胞中P-ERK 1/2的表达[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
• 体外研究: CB2受体激动剂3(化合物2a)在基于人类早幼粒细胞白血病HL-60细胞的体外模型中也显示为激动剂[1]。
• 参考文献:

  [1]. Murineddu G, et al. Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. J Med Chem. 2006;49(25):7502-7512.

CB2 receptor agonist 3物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 632.9±55.0 °C at 760 mmHg
• 分子式: C₂₄H₂₃Cl₂N₃O
• 分子量: 440.365
• 闪点: 336.6±31.5 °C
• 精确质量: 439.121826
• PSA: 46.92000
• LogP: 6.58
• InChIKey: SPEFJYZGXZENAF-UHFFFAOYSA-N
• SMILES: Cc1ccc2c(c1)Cc1c(C(=O)NC3CCCCC3)nn(-c3ccc(Cl)cc3Cl)c1-2
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.700

CB2 receptor agonist 3靶点实验

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实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Intrinsic activity at CB2 receptor assessed as induction of ERK1/2 phosphorylation in... 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL910421

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Selectivity for CD1 mouse CB2 receptor over CB1 receptor 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL911050

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Displacement of [3H]CP 55940 from human CB2 receptor in cell free system 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL1670561

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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CB2 receptor agonist 3英文别名

• nor-Binaltorphimine dihydrochloride
• HMS3269N05
• N-Cyclohexyl-1-(2,4-dichlorophenyl)-6-methyl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide
• GP 2A