Cerlapirdine

• 常用名: Cerlapirdine
• 英文名: Cerlapirdine
• CAS号: 925448-93-7
• 分子量: 409.50100
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₃N₃O₃S
• 熔点: N/A
• 闪点: N/A

Cerlapirdine用途

Cerlapirdine(SAM-531,PF-05212365)是一种选择性和有效的5-羟色胺6(5-HT6)受体完全拮抗剂。Cerlapirdine具有研究阿尔茨海默病的潜力[1]。

Cerlapirdine名称

• 英文名: N,N-dimethyl-3-[(3-naphthalen-1-ylsulfonyl-2H-indazol-5-yl)oxy]propan-1-amine

Cerlapirdine生物活性

• 描述: Cerlapirdine(SAM-531,PF-05212365)是一种选择性和有效的5-羟色胺6(5-HT6)受体完全拮抗剂。Cerlapirdine具有研究阿尔茨海默病的潜力[1]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点实验:

  5-HT6 Receptor

• 参考文献:

  [1]. Tse S, et al. Disposition and metabolic profiling of [(14)C]cerlapirdine using accelerator mass spectrometry. Drug Metab Dispos. 2014;42(12):2023-2032.

Cerlapirdine物理化学性质

• 分子式: C₂₂H₂₃N₃O₃S
• 分子量: 409.50100
• 精确质量: 409.14600
• PSA: 83.67000
• LogP: 4.96020
• InChIKey: NXQGEDVQXVTCDA-UHFFFAOYSA-N
• SMILES: CN(C)CCCOc1ccc2n[nH]c(S(=O)(=O)c3cccc4ccccc34)c2c1

Cerlapirdine靶点实验

查看更多实验

实验名称：Reversal of time-induced amnesia in Wistar rat at 1 to 3 mg/kg, sc administered 60 mi... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4009057

实验名称：Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 6 External Id：CHEMBL3371192

实验名称：Human 5-HT6 receptor (5-Hydroxytryptamine receptors) 来源：IUPHAR-DB 靶标：5-HT6 receptor (5-Hydroxytryptamine receptors) [Homo sapiens] External Id：11_Human

实验名称：Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constant 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 6 External Id：CHEMBL5215990

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Cerlapirdine英文别名

• SAM-531
• UNII-EK40PJ0V49
• Cerlapirdine