NVP-BHG 712

• 常用名: NVP-BHG 712
• 英文名: NVP-BHG712
• CAS号: 940310-85-0
• 分子量: 503.478
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₆H₂₀F₃N₇O
• 熔点: N/A
• 闪点: N/A
• 符号: GHS06
• 信号词: Danger

NVP-BHG 712用途

NVP-BHG712是EphB4抑制剂,ED50为25 nM,对c-Raf,c-Src和c-Abl的IC50分别为0.395 μM,1.266 μM和1.667 μM。

NVP-BHG 712名称

• 中文名: 4-甲基-3-[[1-甲基-6-(3-吡啶基)-1H-吡唑并[3,4-d]嘧啶-4-基]氨基]-N-[3-(三氟甲基)苯基]苯甲酰胺
• 英文名: 4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide

NVP-BHG 712生物活性

• 描述: NVP-BHG712是EphB4抑制剂,ED50为25 nM,对c-Raf,c-Src和c-Abl的IC50分别为0.395 μM,1.266 μM和1.667 μM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> 艾弗林受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Martiny-Baron G, et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 2010 Sep;13(3):259-67.

NVP-BHG 712物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₆H₂₀F₃N₇O
• 分子量: 503.478
• 精确质量: 503.168152
• PSA: 101.11000
• LogP: 4.05
• InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
• SMILES: Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
• 外观性状: white to beige
• 折射率: 1.666
• 储存条件: ?20°C
• 水溶解性: DMSO: >15mg/mL

NVP-BHG 712安全信息

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301
• 警示性声明: P301 + P310
• 危害码 (欧洲): T
• 风险声明 (欧洲): 25
• 安全声明 (欧洲): 45
• 危险品运输编码: UN 2811 6.1 / PGIII

NVP-BHG 712靶点实验

查看更多实验

实验名称：Binding affinity to human FGFR1 incubated for 45 mins by Kinobead based pull down ass... 来源：ChEMBL 靶标：Fibroblast growth factor receptor 1 External Id：CHEMBL5651426

实验名称：Binding affinity to human FIBP incubated for 45 mins by Kinobead based pull down assa... 来源：ChEMBL 靶标：Acidic fibroblast growth factor intracellular-binding protein External Id：CHEMBL5651428

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Binding affinity to human FKBP1A incubated for 45 mins by Kinobead based pull down as... 来源：ChEMBL 靶标：Peptidyl-prolyl cis-trans isomerase FKBP1A External Id：CHEMBL5651430

实验名称：Binding affinity to human FKBP4 incubated for 45 mins by Kinobead based pull down ass... 来源：ChEMBL 靶标：Peptidyl-prolyl cis-trans isomerase FKBP4 External Id：CHEMBL5651432

实验名称：Binding affinity to human FLNA incubated for 45 mins by Kinobead based pull down assa... 来源：ChEMBL 靶标：Filamin-A External Id：CHEMBL5651435

实验名称：Binding affinity to human FLT3 incubated for 45 mins by Kinobead based pull down assa... 来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3 External Id：CHEMBL5651437

实验名称：Binding affinity to human FN3K incubated for 45 mins by Kinobead based pull down assa... 来源：ChEMBL 靶标：Fructosamine-3-kinase External Id：CHEMBL5651439

实验名称：Binding affinity to human FN3KRP incubated for 45 mins by Kinobead based pull down as... 来源：ChEMBL 靶标：Ketosamine-3-kinase External Id：CHEMBL5651440

实验名称：Binding affinity to human FRK incubated for 45 mins by Kinobead based pull down assay 来源：ChEMBL 靶标：Tyrosine-protein kinase FRK External Id：CHEMBL5651441

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NVP-BHG 712英文别名

• NVP-BHG712
• 4-Methyl-3-{[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-[3-(trifluoromethyl)phenyl]benzamide
• 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide
• cc-540
• S2202_Selleck