BAL-30072

• 常用名: BAL-30072
• 英文名: BAL-30072
• CAS号: 941285-15-0
• 分子量: 518.47800
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₈N₆O₁₀S₂
• 熔点: N/A
• 闪点: N/A

BAL-30072用途

BAL-30072 是一种磺胺嘧啶类的单环 β-内酰胺类抗生素,据有抗多重耐药革兰氏阴性杆菌的活性。BAL-30072 对多耐药型Acinetobacter spp. 和P. aeruginosa 的 MIC90 值分别为 4 μg/mL 和 8 μg/mL。

BAL-30072名称

• 英文名: [(3S)-3-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(1,5-dihydroxy-4-oxopyridin-2-yl)methoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate

BAL-30072生物活性

• 描述: BAL-30072 是一种磺胺嘧啶类的单环 β-内酰胺类抗生素,据有抗多重耐药革兰氏阴性杆菌的活性。BAL-30072 对多耐药型Acinetobacter spp. 和P. aeruginosa 的 MIC90 值分别为 4 μg/mL 和 8 μg/mL。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  MIC90: 4 μg/mL (MDR Acinetobacter spp.), 8 μg/mL (MDR P. aeruginosa)[1][2].

• 参考文献:

  [1]. Page MG, et al. In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. Antimicrob Agents Chemother. 2010 Jun;54(6):2291-302.

  [2]. Michael Hornsey, et al. In vitro activity of the novel monosulfactam BAL30072 alone and in combination with meropenem versus a diverse collection of important Gram-negative pathogens. Int J Antimicrob Agents. 2013 Oct;42(4):343-6.

BAL-30072物理化学性质

• 分子式: C₁₆H₁₈N₆O₁₀S₂
• 分子量: 518.47800
• 精确质量: 518.05300
• PSA: 276.81000
• LogP: 0.37990
• InChIKey: KLFSEZJCLYBFKQ-WXYNYTDUSA-N
• SMILES: CC1(C)C(NC(=O)C(=NOCc2cc(=O)c(O)cn2O)c2csc(N)n2)C(=O)N1OS(=O)(=O)O

BAL-30072靶点实验

查看更多实验

实验名称：Antimicrobial activity against Pseudomonas aeruginosa PAO1 by broth dilution method 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1260258

实验名称：Antimicrobial activity against oprD protein deficient Pseudomonas aeruginosa C2 by br... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1260257

实验名称：Antimicrobial activity against Pseudomonas aeruginosa B4 by broth dilution method 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1260256

实验名称：Antimicrobial activity against Acinetobacter baumannii HPA I-16 harboring beta-lactam... 来源：ChEMBL 靶标：Acinetobacter baumannii External Id：CHEMBL1260255

实验名称：Antimicrobial activity against Acinetobacter baumannii HPA 4737 harboring beta-lactam... 来源：ChEMBL 靶标：Acinetobacter baumannii External Id：CHEMBL1260254

实验名称：Antimicrobial activity against Acinetobacter baumannii HPA 327009 harboring beta-lact... 来源：ChEMBL 靶标：Acinetobacter baumannii External Id：CHEMBL1260936

实验名称：Antimicrobial activity against Serratia marcescens 1T9 harboring beta-lactamase Class... 来源：ChEMBL 靶标：Serratia marcescens External Id：CHEMBL1260935

实验名称：Antimicrobial activity against Pseudomonas aeruginosa 18S/H harboring beta-lactamase ... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1260934

实验名称：Antimicrobial activity against Pseudomonas aeruginosa BA(C2-107) selected after 25 ug... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1260266

实验名称：Antimicrobial activity against pfeA deficient Pseudomonas aeruginosa 134 by broth dil... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1260265

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BAL-30072英文别名

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• unii-ly97zjm4qx