BNC105

• 常用名: BNC105
• 英文名: BNC105
• CAS号: 945771-74-4
• 分子量: 372.36900
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₀O₇
• 熔点: N/A
• 闪点: N/A

BNC105用途

BNC105是新乡微管多聚抑制剂，抗肿瘤和血管阻断剂。

BNC105名称

• 中文名: BNC105
• 英文名: (7-hydroxy-6-methoxy-2-methyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone

BNC105生物活性

• 描述: BNC105是新乡微管多聚抑制剂,抗肿瘤和血管阻断剂。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54(17):6014-27.

  [2]. Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9(6):1562-73.

  [3]. Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15(11):1552-60.

BNC105物理化学性质

• 分子式: C₂₀H₂₀O₇
• 分子量: 372.36900
• 精确质量: 372.12100
• PSA: 87.36000
• LogP: 3.71220
• InChIKey: RADMJHVVIZTENA-UHFFFAOYSA-N
• SMILES: COc1cc(C(=O)c2c(C)oc3c(O)c(OC)ccc23)cc(OC)c1OC
• 储存条件: 2-8℃

BNC105靶点实验

查看更多实验

实验名称：Antiproliferative activity against HUVEC grown in absence of growth factors after 48 ... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL1828307

实验名称：Antiproliferative activity against HUVEC grown in presence of growth factors after 48... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL1828306

实验名称：Selectivity ratio of IC50 for HUVEC grown in absence of growth factors to IC50 for HU... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL1828308

实验名称：Selectivity ratio of IC50 for human HAAE1 grown in absence of growth factors to IC50 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1828311

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Aqueous solubility of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL1828333

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Drug uptake in tumor of MDA-MB-231 breast cancer BALB/c mouse model at 1 to 150 mg/kg... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1828334

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

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BNC105英文别名

• 2-methyl-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan
• (7-hydroxy-6-methoxy-2-methylbenzofuran-3-yl)(3,4,5-trimethoxyphenyl)methanone
• UNII-Z3S2Z6H7B0
• 2-methyl-3-(3,4,5-trimethoxybenzoyl)-7-hydroxy-6-methoxy-benzo[b]furan
• 2-methyl-3-(3,4,5-trimethoxybenzoyl)-6-methoxy-7-hydroxy-benzo[b]furan
• 2-methyl-7-hydroxy-3-(3,4,5-trimethoxybenzoyl)-6-methoxybenzofuran
• BNC105