(R)-(+)-卡维地洛

• 常用名: (R)-(+)-卡维地洛
• 英文名: (R)-(+)-Carvedilol
• CAS号: 95093-99-5
• 分子量: 406.47400
• 密度: 1.25g/cm3
• 沸点: 655.2ºC at 760 mmHg
• 分子式: C₂₄H₂₆N₂O₄
• 熔点: 114-115ºC
• 闪点: 350.1ºC

(R)-(+)-卡维地洛用途

(R)-Carvedilol ((R)-BM 14190) 是 Carvedilol 的 R 型异构体,是一种非选择性 β/α-1 受体阻断剂。(R)-Carvedilol 可以抵抗 Doxorubicin (DOX) 的血管或心脏毒性。

(R)-(+)-卡维地洛名称

• 中文名: (R)-(+)-卡维地洛
• 英文名: (2R)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
• 中文别名: 卡维地络杂质B

(R)-(+)-卡维地洛生物活性

• 描述: (R)-Carvedilol ((R)-BM 14190) 是 Carvedilol 的 R 型异构体,是一种非选择性 β/α-1 受体阻断剂。(R)-Carvedilol 可以抵抗 Doxorubicin (DOX) 的血管或心脏毒性。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
• 靶点实验:

  β/α-1 adrenergic receptor[1]

• 参考文献:

  [1]. Wu T, et al. Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39(8):1233-1244.

(R)-(+)-卡维地洛物理化学性质

• 密度: 1.25g/cm3
• 沸点: 655.2ºC at 760 mmHg
• 熔点: 114-115ºC
• 分子式: C₂₄H₂₆N₂O₄
• 分子量: 406.47400
• 闪点: 350.1ºC
• 精确质量: 406.18900
• PSA: 75.74000
• LogP: 4.12890
• InChIKey: OGHNVEJMJSYVRP-QGZVFWFLSA-N
• SMILES: COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12
• 折射率: 1.657
• 储存条件: 2-8°C

(R)-(+)-卡维地洛靶点实验

查看更多实验

实验名称：Displacement of [3H]-CGP-12177 from murine beta1-adrenergic receptor expressed in HEK... 来源：ChEMBL 靶标：Beta-1 adrenergic receptor External Id：CHEMBL4397555

实验名称：Displacement of [3H]-CGP-12177 from human beta2-adrenergic receptor expressed in CHO ... 来源：ChEMBL 靶标：Beta-2 adrenergic receptor External Id：CHEMBL4397556

实验名称：Induction Ca2+ levels in CHO cells by FLIPR calcium 4 assay 来源：ChEMBL 靶标：CHO External Id：CHEMBL4429652

实验名称：Displacement of [3H]CGP12177 from human beta2 receptor expressed in CHO cells 来源：ChEMBL 靶标：Beta-2 adrenergic receptor External Id：CHEMBL3801474

实验名称：Agonist activity at beta1-adrenergic receptor (unknown origin) expressed in HEK293T c... 来源：ChEMBL 靶标：Beta-1 adrenergic receptor External Id：CHEMBL4397557

实验名称：Induction Ca2+ levels in CHO cells at 1 uM by FLIPR calcium 4 assay 来源：ChEMBL 靶标：CHO External Id：CHEMBL4429653

实验名称：Agonist activity at human OX1 receptor expressed in CHO cell membranes assessed as in... 来源：ChEMBL 靶标：Orexin/Hypocretin receptor type 1 External Id：CHEMBL4429654

实验名称：Agonist activity at beta1-adrenergic receptor (unknown origin) expressed in HEK293T c... 来源：ChEMBL 靶标：Beta-1 adrenergic receptor External Id：CHEMBL4397559

实验名称：Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membran... 来源：ChEMBL 靶标：Orexin/Hypocretin receptor type 1 External Id：CHEMBL4429655

实验名称：Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membran... 来源：ChEMBL 靶标：Orexin receptor type 2 External Id：CHEMBL4429656

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(R)-(+)-卡维地洛英文别名

• (R)-(+)-Carvedilol
• S-(-)-1-(carbazol-4-yloxy)-3-[[2-(O-methoxyphenoxy)ethyl]amino]-2-propanol
• (S)-carvedilol
• (+)-Carvedilol
• Carvedilol Impurity 10