Chloroquinoxaline sulfonamide

• 常用名: Chloroquinoxaline sulfonamide
• 英文名: Chloroquinoxaline sulfonamide
• CAS号: 97919-22-7
• 分子量: 334.78100
• 密度: 1.569g/cm3
• 沸点: 576.3ºC at 760mmHg
• 分子式: C₁₄H₁₁ClN₄O₂S
• 熔点: N/A
• 闪点: 302.3ºC

Chloroquinoxaline sulfonamide用途

Chloroquinoxaline sulfonamide (Chloroquinoxaline) 是 sulfaquinoxaline 的结构类似物,是拓扑异构酶 II alpha/beta (topoisomerase II alpha/beta) 毒物。Chloroquinoxaline sulfonamide 用于控制家禽,兔,绵羊和牛的球虫病。 具有抗肿瘤活性。

Chloroquinoxaline sulfonamide名称

• 英文名: 4-amino-N-(5-chloroquinoxalin-2-yl)benzenesulfonamide

Chloroquinoxaline sulfonamide生物活性

• 描述: Chloroquinoxaline sulfonamide (Chloroquinoxaline) 是 sulfaquinoxaline 的结构类似物,是拓扑异构酶 II alpha/beta (topoisomerase II alpha/beta) 毒物。Chloroquinoxaline sulfonamide 用于控制家禽,兔,绵羊和牛的球虫病。 具有抗肿瘤活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶
  研究领域 >> 感染
• 靶点实验:

  topoisomerase II alpha

  topoisomerase II beta

• 体外研究: 用MTT法测定CV-1细胞的氯喹啉磺胺IC50为1.8mm。氯喹恶啉磺胺类药物经GuHCl裂解终止药物治疗后,引起CV-1猴肾细胞染色体DNA与剂量依赖性蛋白DNA交联。氯喹恶啉磺胺诱导CV-1细胞蛋白质DNA交联。氯喹恶啉磺胺诱导拓扑异构酶II-DNA交联[1]。氯喹恶啉磺胺(氯喹恶啉)是磺胺喹恶啉的氯化衍生物,可抑制小鼠B16黑色素瘤细胞的增殖,但仅当使用相对较高的药物浓度(1 mM)时[2]。细胞增殖实验[2]细胞系：B16小鼠黑色素瘤细胞浓度：10μM、100μM、1mm孵育时间：24、48、72小时结果：抑制了小鼠B16黑色素瘤细胞的增殖,但仅在药物浓度相对较高(1mm)时。
• 参考文献:

  [1]. Gao H, et al. Chloroquinoxaline sulfonamide (NSC 339004) is a topoisomerase IIalpha/beta poison. Cancer Res. 2000 Nov 1;60(21):5937-40.

  [2]. Branda RF, et al. Cellular pharmacology of chloroquinoxaline sulfonamide and a related compound in murine B16 melanoma cells. Biochem Pharmacol. 1988 Dec 1;37(23):4557-64.

Chloroquinoxaline sulfonamide物理化学性质

• 密度: 1.569g/cm3
• 沸点: 576.3ºC at 760mmHg
• 分子式: C₁₄H₁₁ClN₄O₂S
• 分子量: 334.78100
• 闪点: 302.3ºC
• 精确质量: 334.02900
• PSA: 106.35000
• LogP: 4.40120
• InChIKey: CTSNHMQGVWXIEG-UHFFFAOYSA-N
• SMILES: Nc1ccc(S(=O)(=O)Nc2cnc3c(Cl)cccc3n2)cc1
• 折射率: 1.734

Chloroquinoxaline sulfonamide毒性和生态

Chloroquinoxaline sulfonamide安全信息

• 海关编码: 2935009090

Chloroquinoxaline sulfonamide海关

• 海关编码: 2935009090
• 中文概述: 2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Chloroquinoxaline sulfonamide靶点实验

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实验名称：Luminescence-based cell-based high throughput dose response assay to identify activat... 来源：The Scripps Research Institute Molecular Screening Center 靶标：SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a [Homo sapiens] External Id：BRM_ACT_LUMI_1536_3XEC50 DRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Bas... 来源：Broad Institute 靶标：N/A External Id：2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Prima... 来源：NCGC 靶标：apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] External Id：AMA1100

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Chloroquinoxaline sulfonamide英文别名

• Chlorsulfaquinoxaline
• chloroquinoxaline sulfonamide
• Sulfanilsaeure-(5-chlor-chinoxalin-2-ylamid)
• 4-Amino-N-(5-chloro-2-quinoxalinyl)benzenesulfonamide
• 5-Chloroquinoxaline-2-sulfanilamide
• sulfanilic acid-(5-chloro-quinoxalin-2-ylamide)