Thiomorpholine Hydrochloride
Thiomorpholine Hydrochloride structure
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Common Name | Thiomorpholine Hydrochloride | ||
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| CAS Number | 5967-90-8 | Molecular Weight | 139.64700 | |
| Density | 1.09 g/mL at 25 °C(lit.) | Boiling Point | 170ºC at 760 mmHg | |
| Molecular Formula | C4H10ClNS | Melting Point | 174-177ºC | |
| MSDS | USA | Flash Point | 60ºC | |
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Redox-neutral α-sulfenylation of secondary amines: ring-fused N,S-acetals.
Org. Lett. 16(13) , 3556-9, (2014) Secondary amines react with thiosalicylaldehydes in the presence of catalytic amounts of acetic acid to generate ring-fused N,S-acetals in redox-neutral fashion. A broad range of amines undergo α-sulfenylation, including challenging substrates such morpholine... |
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A convenient route to optically pure α-alkyl-β-(sec-amino)alanines.
Amino Acids 42(6) , 2525-8, (2012) The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The re... |
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One-pot multicomponent synthesis of two novel thiolactone scaffolds.
Mol. Divers. 14(3) , 479-91, (2010) We designed two novel thiolactone scaffolds. Both scaffolds can be accessed by a convergent Ugi multicomponent reaction (MCR) and are, thus, amenable to library synthesis. Design, stereoselectivity, structures, full experimental details, and virtual libraries... |
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Natural abundance nitrogen-15 nuclear magnetic resonance spectral studies on selected donors.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 58(12) , 2737-57, (2002) The natural abundance 15N-NMR chemical shifts of selected aliphatic amines, 2-substituted pyridine type compounds, bialicyclic tertiary amines have been measured as a function of the nature of the solvent. In the case of cyclic aliphatic amines, like piperidi... |
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SnAP reagents for the transformation of aldehydes into substituted thiomorpholines--an alternative to cross-coupling with saturated heterocycles.
Angew. Chem. Int. Ed. Engl. 52(6) , 1705-8, (2013)
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Synthesis of novel N-hydroxy heterocycles via intramolecular reductive cyclization of diketoximes by NaBH3CN.
Org. Biomol. Chem. 9 , 4642, (2011) A simple and efficient protocol for the construction of substituted piperazines, piperidines, thiomorpholines, decahydroquinolines, perhydrocyclopenta[b]pyridine, and pyrrolidines bearing N-hydroxy substituents through intramolecular reductive cyclization of ... |
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Common degradative pathways of morpholine, thiomorpholine, and piperidine by Mycobacterium aurum MO1: evidence from (1)H-nuclear magnetic resonance and ionspray mass spectrometry performed directly on the incubation medium.
Appl. Environ. Microbiol. 66(8) , 3187-93, (2000) In order to see if the biodegradative pathways for morpholine and thiomorpholine during degradation by Mycobacterium aurum MO1 could be generalized to other heterocyclic compounds, the degradation of piperidine by this strain was investigated by performing (1... |
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[Study of antiradiation drugs. I. Synthesis of some mercapto and amino derivatives of thiomorpholine (author's transl)].
Yao Xue Xue Bao 15(8) , 482-8, (1980)
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[Thiomorpholine transformation by the fungus Bjerkandera adusta].
Mikrobiologiia 77(5) , 617-22, (2008) A screening of lignin-degrading basidial fungi that can grow in the presence of thiomorpholine derivatives (the mixture of 1,4-perhydrothiazines) has been performed. Strain Bjerkandera adusta VKM F-3477 was shown to have the maximal rate of growth in the pres... |
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I2-mediated diversity oriented diastereoselective synthesis of amino acid derived trans-2,5-disubstituted morpholines, piperazines, and thiomorpholines.
ACS Comb. Sci. 14(1) , 1-4, (2012) Diastereoselective trans-2,5-disubstituted amino acids derived diverse morpholines, piperazines and thiomorpholines were prepared in 30 min-1 h with high yields through iodine-mediated 6-exotrig type cyclization from a single common synthetic intermediate. Th... |