5μ-Inosinic acid hydrate disodium salt,I-5μ-P,IMP,Inosinic Acid
5μ-Inosinic acid hydrate disodium salt,I-5μ-P,IMP,Inosinic Acid structure
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Common Name | 5μ-Inosinic acid hydrate disodium salt,I-5μ-P,IMP,Inosinic Acid | ||
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| CAS Number | 352195-40-5 | Molecular Weight | 410.18500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H13N4Na2O9P | Melting Point | 175ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
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The role of inosine-5'-monophosphate dehydrogenase in thiopurine metabolism in patients with inflammatory bowel disease.
Ther. Drug Monit. 33 , 200-208, (2011) There is a large interindividual variability in thiopurine metabolism. High concentrations of methylthioinosine-5'-monophosphate (meTIMP) and low concentrations of 6-thioguanine nucleotides (6-TGNs) have been associated with a lower response rate and an incre... |
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The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors.
Curr. Med. Chem. 18 , 1909-1918, (2011) Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes the first committed step of guanosine 5'-monophosphate (GMP) biosynthesis, and thus regulates the guanine nucleotide pool, which in turn governs proliferation. Human IMPDHs are validated targets for imm... |
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Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection.
Int. Immunopharmacol. 10 , 91-97, (2010) Routine laboratory data are not adequately used to follow a patient because medical students are not educated to comprehend them with time series analysis. The Department of Laboratory Medicine can support physicians by adding comments to laboratory data that... |
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A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi.
BMC Microbiol. 11 , 202, (2011) Many secondary metabolites produced by filamentous fungi have potent biological activities, to which the producer organism must be resistant. An example of pharmaceutical interest is mycophenolic acid (MPA), an immunosuppressant molecule produced by several P... |
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The Cys319 loop modulates the transition between dehydrogenase and hydrolase conformations in inosine 5'-monophosphate dehydrogenase.
Biochemistry 49 , 10674-10681, (2010) X-ray crystal structures of enzyme-ligand complexes are widely believed to mimic states in the catalytic cycle, but this presumption has seldom been carefully scrutinized. In the case of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase (IMPDH), 10... |
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Guanosine supplementation reduces the antiproliferative and apoptotic effects of the IMPDH inhibitor gnidilatimonoein in K562 cells.
Cell Biol. Int. 35 , 1001-1008, (2011) IMPDH (inosine 5'-monophosphate dehydrogenase) is the rate-limiting enzyme in the de novo biosynthetic pathway of guanine nucleotides, which is usually up-regulated in human leukaemia cell lines. Our previous studies have classified gnidilatimonoein, isolated... |
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Inosine 5'-monophosphate dehydrogenase activity as a biomarker in the field of transplantation. Glander P, Hambach P, et al.
Clin. Chim. Acta 68(6) , 913-22, (2011)
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Inosine 5′-monophosphate dehydrogenase activity as a biomarker in the field of transplantation. Glander P, Hambach P, et al.
Clin. Chim. Acta , (2011)
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