3,4-Dichlorophenylacetic acid

3,4-Dichlorophenylacetic acid Structure
3,4-Dichlorophenylacetic acid structure
Common Name 3,4-Dichlorophenylacetic acid
CAS Number 5807-30-7 Molecular Weight 205.038
Density 1.5±0.1 g/cm3 Boiling Point 328.0±27.0 °C at 760 mmHg
Molecular Formula C8H6Cl2O2 Melting Point 89-91 °C(lit.)
MSDS Chinese USA Flash Point 152.1±23.7 °C

Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands.

J. Med. Chem. 32 , 1996, (1989)

The synthesis and in vitro sigma receptor activity of the two diastereomers of U50,488 [(+/-)-2], namely, (1R,2S)-(+)- cis-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacet ami de [(+)-1] and (1S,2R)-(-)-cis-3,4-dichloro- N-methyl-N-[2-(1-pyrr...

4-[(Alkylamino)methyl]furo[3,2-c]pyridines: a new series of selective kappa-receptor agonists.

J. Med. Chem. 37 , 2138, (1994)

The synthesis of 5-(arylacetyl)-4-[(alkylamino)methyl]furo[3,2-c] pyridines (16-23, 26, 27) and their activities as kappa-opioid receptor agonists are described. kappa-Agonist potency was particularly sensitive to the nature of the basic moiety. In particular...