amitriptyline metabolite (+/-)-
amitriptyline metabolite (+/-)- structure
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Common Name | amitriptyline metabolite (+/-)- | ||
|---|---|---|---|---|
| CAS Number | 64520-05-4 | Molecular Weight | 293.40300 | |
| Density | 1.151g/cm3 | Boiling Point | 453.3ºC at 760mmHg | |
| Molecular Formula | C20H23NO | Melting Point | 97-99 °C | |
| MSDS | USA | Flash Point | 225.4ºC | |
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Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes.
Clin. Pharmacol. Ther. 52(4) , 350-8, (1992) In 26 hospitalized patients with depression, a combined pharmacogenetic test with dextromethorphan, a substrate of cytochrome P450IID6, and mephenytoin, the S-form of which is hydroxylated by a P450IIC isozyme, was carried out before amitriptyline therapy. Me... |
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Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes.
Drug Metab. Dispos. 9(6) , 565-8, (1981) The rates of demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline by microsomes from adult human livers were determined by use of mass-fragmentographic or liquid-chromatographic quantitation of the formed metabolites. T... |
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CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies.
Forensic Sci. Int. 158(2-3) , 177-83, (2006) In a series of 202 postmortem toxicology cases, the CYP2D6 and CYP2C19 genes were genotyped, and the concentrations of amitriptyline (AT) and six metabolites were analyzed. The polymorphic CYP2D6 and CYP2C19 genes encode enzymes participating in the metabolis... |
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Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin.
Int. Clin. Psychopharmacol. 1(2) , 102-12, (1986) A subgroup of 16 out of 30 endogenous depressive inpatients (cf. part I), treated for 3 weeks with 150 mg amitriptyline (AT) daily, participated in a pharmacogenetic study: all were phenotyped with debrisoquine and 3 of them with mephenytoin. Four patients we... |
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[Relationship between amitriptyline metabolism and polymorphic debrisoquine hydroxylation in native Chinese volunteers].
Yao Xue Xue Bao 28(2) , 85-91, (1993) The demethylation and hydroxylation of amitriptyline were calculated from the ratios between the area under concentration--time curve (AUC) of amitriptyline and its three metabolites in eight healthy Chinese volunteers after a single oral dose of 100 mg amitr... |
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[Serum concentrations of amitriptyline and its metabolites and clinical effect in depressive patients].
Zhonghua Shen Jing Jing Shen Ke Za Zhi 25(4) , 196-8, 252, (1992) The serum concentrations of amitriptyline and its 3 metabolites--nortriptyline, 10-hydroxy-amitriptyline and 10-hydroxy-nortriptyline were determined in 18 depressive patients treated with amitriptyline for 6 weeks. The relationships between the serum concent... |
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Metabolism of amitriptyline with CYP2D6 expressed in a human cell line.
Xenobiotica 27(1) , 33-47, (1997) 1. Expressed human cytochrome P450 enzyme CPY2D6 was used to metabolize amitriptyline (AMI). It was established that CYP2D6 not only catalyzed ring 10-hydroxylation of AMI, but also mediated its N-demethylation to nortriptyline (NT), as well as the formation ... |
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Quantification of amitriptyline, nortriptyline, and 10-hydroxy metabolite isomers in plasma by capillary gas chromatography with nitrogen-sensitive detection.
J. Chromatogr. A. 278(2) , 291-9, (1983) A selective, sensitive method for the determination of amitriptyline and its metabolites is described. This method involves liquid-liquid extraction and capillary gas chromatography with nitrogen-sensitive detection. The detection limits of amitriptyline, nor... |
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Amitriptyline and hydroxylated metabolite plasma levels in depressed outpatients.
J. Clin. Psychopharmacol. 5(2) , 83-8, (1985) As part of a double-blind clinical trial comparing phenelzine and amitriptyline in outpatients with predominantly major depressive disorder, plasma tricyclic antidepressant drug concentrations were measured in 83 amitriptyline-treated patients. In 29 of these... |
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Enantiomer analysis of E- and Z-10-hydroxyamitriptyline in human urine.
J. Chromatogr. A. 528(1) , 163-71, (1990) E- and Z-10-hydroxyamitriptyline (E- and Z-10-OH-AT) are racemic alcoholic metabolites of the antidepressant amitriptyline. Their enantiomers were separated by high-performance liquid chromatography as diastereomeric derivatives using R-(+)-alpha-methoxy-alph... |