(S)-tert-Butyl 2-cyanopyrrolidine-1-carboxylate
(S)-tert-Butyl 2-cyanopyrrolidine-1-carboxylate structure
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Common Name | (S)-tert-Butyl 2-cyanopyrrolidine-1-carboxylate | ||
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| CAS Number | 228244-04-0 | Molecular Weight | 196.246 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 307.9±35.0 °C at 760 mmHg | |
| Molecular Formula | C10H16N2O2 | Melting Point | 33-36ºC | |
| MSDS | Chinese | Flash Point | 140.0±25.9 °C | |
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New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides.
J. Med. Chem. 46 , 4543, (2003) Isophthalic acid bis(l-prolyl-pyrrolidine) amide is a very potent prolyl oligopeptidase inhibitor, but it has a log P value of -0.2, which is very low for a compound targeted to the brain. Therefore, these types of compounds were further modified to improve t... |
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Constrained peptidomimetics reveal detailed geometric requirements of covalent prolyl oligopeptidase inhibitors.
J. Med. Chem. 52 , 6672-84, (2009) Prolyl oligopeptidases cleave peptides on the carboxy side of internal proline residues and their inhibition has potential in the treatment of human brain disorders. Using our docking program fitted, we have designed a series of constrained covalent inhibitor... |
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