PD128907 HCl
PD128907 HCl structure
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Common Name | PD128907 HCl | ||
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| CAS Number | 112960-16-4 | Molecular Weight | 285.77 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H20ClNO3 | Melting Point | 145-153°C | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907.
J. Pharmacol. Exp. Ther. 275 , 1355, (1995) The present study determined the biochemical and pharmacological effects of PD 128907 [R-(+)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H- [1]benzopyrano[4,3-b]-1,4-oxazin-9-ol], a dopamine (DA) receptor agonist that shows a preference for the human D3 receptor... |
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Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers.
J. Med. Chem. 33 , 445-450, (1990) The dopamine agonist profile of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol (16a) and its enantiomers (16b-c) was examined. Racemic 16a exhibited moderate affinity for the dopamine (DA) D2 receptor labeled with the D... |
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Dopamine D3 (auto) receptors inhibit dopamine release in the frontal cortex of freely moving rats in vivo.
J. Neurochem. 66 , 2209, (1996) In freely moving rats, the novel, selective dopamine (DA) D3 receptor agonist PD 128,907 dose-dependently [effective dose (ED25) = 0.07 mg/kg, s.c.] reduced dialysate levels of DA in the frontal cortex, a structure innervated by the ventral tegmental area (VT... |