zingerone
zingerone structure
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Common Name | zingerone | ||
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| CAS Number | 122-48-5 | Molecular Weight | 194.227 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 323.0±27.0 °C at 760 mmHg | |
| Molecular Formula | C11H14O3 | Melting Point | 40-41 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 123.7±17.2 °C | |
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Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves.
Life Sci. 92(6-7) , 368-78, (2013) Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1) channels but also inhibits nerve conduction, the latter action has not yet been fully examined. The purpose of the present study was to know whether various vanilloids have... |
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Fenugreek extract as an inducer of cellular death via autophagy in human T lymphoma Jurkat cells.
BMC Complement Altern. Med. 12 , 202, (2012) Drugs used both in classical chemotherapy and the more recent targeted therapy do not have cancer cell specificity and, hence, cause severe systemic side effects. Tumors also develop resistance to such drugs due to heterogeneity of cell types and clonal selec... |
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Targeting antioxidative signal transduction and stress response system: control of pathogenic Aspergillus with phenolics that inhibit mitochondrial function.
J. Appl. Microbiol. 101(1) , 181-9, (2006) The aim of this study was to show whether antioxidative response systems are potentially useful molecular targets for control of Aspergillus fumigatus and Aspergillus flavus. Selected phenolic agents are used in target-gene-based bioassays to determine their ... |
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Temporal interactions between oral irritants: piperine, zingerone, and capsaicin.
Chem. Senses 32(5) , 455-62, (2007) Sequential presentation of 2 irritants may produce cross-sensitization or cross-adaptation effects upon introduction of the second irritant. In Experiment 1, subjects were given either 34 min of stimulation with zingerone, capsaicin, or piperine or one of tho... |
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Peroxisome proliferator-activated receptor activation by a short-term feeding of zingerone in aged rats.
J. Med. Food 12(2) , 345-50, (2009) Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, are key regulators of various metabolic pathways related to lipid and glucose metabolism as well as inflammation. We examined the effect of zingerone, a major... |
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Effects of zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] and eugenol [2-methoxy-4-(2-propenyl)phenol] on the pathological progress in the 6-hydroxydopamine-induced Parkinson's disease mouse model.
Neurochem. Res. 36(12) , 2244-9, (2011) Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons in the nigrostriatal system and dopamine (DA) depletion in the striatum. The most popular therapeutic medicine for treating PD, 3-(3,4-Dihydroxyphenyl)-L-alanine (L-... |
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Manganese peroxidase-catalyzed oxidative degradation of vanillylacetone.
Chemosphere 72(4) , 572-7, (2008) When 4-(4-hydroxy-3-methoxy-phenyl)-2-butanone (vanillylacetone) was tested for manganese peroxidase (MnP)-catalyzed oxidation, it was found to be degraded with the cleavage of an aromatic ring. Among numerous products of vanillylacetone oxidation, four major... |
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Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats.
J. Nat. Med. 65(1) , 89-94, (2011) Ginger (rhizome of Zingiber officinale Roscoe) is an herbal medicine for the treatment of gastrointestinal disorders including constipation and diarrhea. Zingerone is a likely active constituent responsible for the antidiarrheal activity of ginger. The curren... |
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Intraluminal administration of zingerol, a non-pungent analogue of zingerone, inhibits colonic motility in rats.
Biomed. Res. 32(2) , 181-5, (2011) Zingerone, a pungent component of ginger, may exert beneficial therapeutic effects on hypermotility-induced diarrhea because it has the ability to inhibit contractions of colonic smooth muscles. However, the pungency is undesirable for possible therapeutic us... |
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[Effects of zingerone on fat storage in ovariectomized rats].
Yakugaku Zasshi 128(8) , 1195-201, (2008) We reported that ginger prevented obesity in mice fed a high-fat diet in previous study. In this experiment, we examined the effects of zingerone, the major pungent component of ginger on fat storage in ovariectomized (Ovx) rats. Oral administration of 170 mg... |