6-Chloroguanineriboside structure
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Common Name | 6-Chloroguanineriboside | ||
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CAS Number | 2004-07-1 | Molecular Weight | 301.69 | |
Density | 2.2±0.1 g/cm3 | Boiling Point | 729.9±70.0 °C at 760 mmHg | |
Molecular Formula | C10H12ClN5O4 | Melting Point | 165-167 °C (dec.)(lit.) | |
MSDS | USA | Flash Point | 395.2±35.7 °C |
Preparative electrochemical reduction of 2-amino-6-chloropurine and synthesis of 6-deoxyacyclovir, a fluorescent substrate of xanthine oxidase and a prodrug of acyclovir.
Acta Chem. Scand. B 41 , 701-707, (1987) D.c. polarography of 2-amino-6-chloropurine in aqueous medium over a broad pH range revealed two diffusion waves, the first of which corresponds to reduction of the C(6)-Cl bond, leading to formation of 2-aminopurine in high yield. Condensation of the sodium ... |
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Synthesis of a mutagenic nucleoside, 2'-deoxy-2-(p-nitrophenyl)-adenosine.
Nucleic Acids Symp. Ser. 17 , 141-143, (1986) The reaction of 2-amino-6-chloropurine riboside with i-amyl nitrite in benzene in the presence of Cu2O, followed by treatment with NH3/MeOH gave 2-phenyladenosine (1). The crude sample of 1 was found to be mutagenic to bacteria (Salmonella typhimurium TA 98 a... |
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Synthesis of 6-arylthio analogs of 2',3'-dideoxy-3'-fluoroguanosine and their effect against hepatitis B virus replication.
Nucleosides Nucleotides Nucleic Acids 25 , 655-665, (2006) A key compound, 2-amino-6-chlor-9-(2,3-dideoxy-3-fluoro-beta-D-erythro-pentofuranosyl)puine, was prepared from 2-amino-6-chloropurine riboside in 5 steps, then subjected to the nucleophilic displacement with benzenethiols to afford 6-arylthio congeners. These... |
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