meso-2,3-butanediol

meso-2,3-butanediol Structure
meso-2,3-butanediol structure
Common Name meso-2,3-butanediol
CAS Number 5341-95-7 Molecular Weight 90.12100
Density 0.784g/cm3 Boiling Point 183-184ºC(lit.)
Molecular Formula C4H10O2 Melting Point 32-34ºC(lit.)
MSDS Chinese USA Flash Point 185 °F

The genome of Pelobacter carbinolicus reveals surprising metabolic capabilities and physiological features.

BMC Genomics 13 , 690, (2012)

The bacterium Pelobacter carbinolicus is able to grow by fermentation, syntrophic hydrogen/formate transfer, or electron transfer to sulfur from short-chain alcohols, hydrogen or formate; it does not oxidize acetate and is not known to ferment any sugars or g...

Identification of factors regulating Escherichia coli 2,3-butanediol production by continuous culture and metabolic flux analysis.

J. Microbiol. Biotechnol. 22(5) , 659-67, (2012)

2,3-Butanediol (2,3-BDO) is an organic compound with a wide range of industrial applications. Although Escherichia coli is often used for the production of organic compounds, the wild-type E. coli does not contain two essential genes in the 2,3-BDO biosynthes...

Medium optimization and proteome analysis of (R,R)-2,3-butanediol production by Paenibacillus polymyxa ATCC 12321.

Appl. Microbiol. Biotechnol. 97(2) , 585-97, (2013)

Paenibacillus polymyxa can produce the (R,R)-stereoisomer of 2,3-butanediol (2,3-BDL) which is industrially very useful. Two important factors affecting (R,R)-BDL production by P. polymyxa ATCC 12321, medium composition, and addition of acetic acid to the cul...

Thermal expansion of the cryoprotectant cocktail DP6 combined with synthetic ice modulators in presence and absence of biological tissues.

Cryobiology 65(2) , 117-25, (2012)

This study explores physical effects associated with the application of cryopreservation via vitrification using a class of compounds which are defined here as synthetic ice modulators (SIMs). The general classification of SIMs includes molecules that modulat...

Biocatalytic production of alpha-hydroxy ketones and vicinal diols by yeast and human aldo-keto reductases.

Chem. Biol. Interact. 202(1-3) , 195-203, (2013)

The α-hydroxy ketones are used as building blocks for compounds of pharmaceutical interest (such as antidepressants, HIV-protease inhibitors and antitumorals). They can be obtained by the action of enzymes or whole cells on selected substrates, such as diketo...

Fermentation of biodiesel-derived glycerol by Bacillus amyloliquefaciens: effects of co-substrates on 2,3-butanediol production.

Appl. Microbiol. Biotechnol. 97(17) , 7651-8, (2013)

Cultivation in glycerol instead of sugars inhibits 2,3-butanediol (2,3-BD) production by Bacillus amyloliquefaciens. In this study, we report that B. amyloliquefaciens readily produces 2,3-BD from biodiesel-derived glycerol in the presence of beet molasses as...

Removal of pathogenic factors from 2,3-butanediol-producing Klebsiella species by inactivating virulence-related wabG gene.

Appl. Microbiol. Biotechnol. 97(5) , 1997-2007, (2013)

Klebsiella species are the most extensively studied among a number of 2,3-butanediol (2,3-BDO)-producing microorganisms. The ability to metabolize a wide variety of substrates together with the ease of cultivation made this microorganisms particularly promisi...

Cloning, expression and characterization of meso-2,3-butanediol dehydrogenase from Klebsiella pneumoniae.

Biotechnol. Lett. 34(8) , 1519-23, (2012)

The budC gene encoding the meso-2,3-BDH from Klebsiella pneumoniae XJ-Li was expressed in E. coli BL21 (DE3) pLys. Hypothetical amino acid sequence alignments revealed that the enzyme belongs to the short chain dehydrogenase/reductase family. After purificati...

2,3-Butanediol recovery from fermentation broth by alcohol precipitation and vacuum distillation.

J. Biosci. Bioeng. 117(4) , 464-70, (2014)

This study presents a new and effective downstream process to recover 2,3-butanediol (2,3-BD) from fermentation broth which is produced by a recombinant Klebsiella pneumoniae strain. The ldhA-deficient K. pneumoniae strain yielded about 90 g/L of 2,3-BD, alon...

Metabolic engineering of Bacillus subtilis for enhanced production of acetoin.

Biotechnol. Lett. 34(10) , 1877-85, (2012)

Acetoin is widely used in food and other industries. A bdhA and acoA double-knockout strain of Bacillus subtilis produced acetoin at 0.72 mol/mol, a 16.4 % increased compared to the wild type. Subsequent overexpression of the alsSD operon enhanced the acetola...