4-Phosphopantetheine
4-Phosphopantetheine structure
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Common Name | 4-Phosphopantetheine | ||
|---|---|---|---|---|
| CAS Number | 1019842-99-9 | Molecular Weight | 584.603 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 830.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C36H26O2P2S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 455.8±32.9 °C | |
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Classical and membrane-initiated estrogen signaling in an in vitro model of anterior hypothalamic kisspeptin neurons.
Endocrinology 156 , 2162-73, (2015) The neuropeptide kisspeptin is essential for sexual maturation and reproductive function. In particular, kisspeptin-expressing neurons in the anterior rostral periventricular area of the third ventricle are generally recognized as mediators of estrogen positi... |
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Characterization of Panax ginseng UDP-Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rh1 in Metabolically Engineered Yeasts.
Mol. Plant 8 , 1412-24, (2015) Ginsenosides, the main pharmacologically active natural compounds in ginseng (Panax ginseng), are mostly the glycosylated products of protopanaxadiol (PPD) and protopanaxatriol (PPT). No uridine diphosphate glycosyltransferase (UGT), which catalyzes PPT to pr... |
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Oestradiol Regulates Neuropeptide Y Release and Gene Coupling with the GABAergic and Glutamatergic Synapses in the Adult Female Rat Dentate Gyrus.
J. Neuroendocrinol. 27 , 911-20, (2015) Neuropeptide Y (NPY) is an endogenous modulator of neuronal activity affecting both GABAergic and glutamatergic transmission. Previously, we found that oestradiol modifies the number of NPY immunoreactive neurones in the hippocampal dentate gyrus. In the pres... |
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Adaptive increases in expression and vasodilator activity of estrogen receptor subtypes in a blood vessel-specific pattern during pregnancy.
Am. J. Physiol. Heart Circ. Physiol. 309 , H1679-96, (2015) Normal pregnancy is associated with adaptive hemodynamic, hormonal, and vascular changes, and estrogen (E2) may promote vasodilation during pregnancy; however, the specific E2 receptor (ER) subtype, post-ER signaling mechanism, and vascular bed involved are u... |
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Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas.
BMC Cancer 15 , 524, (2015) Alternate transcripts from a single gene locus greatly enhance the combinatorial flexibility of the human transcriptome. Different patterns of exon usage have been observed when comparing normal tissue to cancers, suggesting that variant transcripts may play ... |
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Methyltransferase-like 17 physically and functionally interacts with estrogen receptors.
IUBMB Life 67 , 861-8, (2016) Estrogen exerts its physiological and pathological functions through two estrogen receptors (ERs), ERα and ERβ, which act as transcription factors. Coregulators, including coactivators and corepressors, have been shown to be crucial for regulation of ER trans... |
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Picropodophyllin inhibits proliferation and survival of diffuse large B-cell lymphoma cells.
Med. Oncol. 32 , 188, (2015) Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. Although chemotherapy in combination with anti-CD20 antibodies results in a cure rate of 60-70 %, novel treatment approaches are warranted for the remaining patients. The insulin-lik... |
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Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2X7 receptors.
Br. J. Pharmacol. 172 , 3326-40, (2015) The P2X7 receptor is an ATP-gated ion channel predominantly expressed in immune cells and plays a key role in inflammatory processes. Ginseng is a well-known Chinese herb with both pro- and anti-inflammatory properties and many of its actions have been ascrib... |
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Estrogen regulates the expression of small-conductance Ca-activated K+ channels in colonic smooth muscle cells.
Digestion 91 , 187-96, (2015) This study aimed to determine the effects of small-conductance Ca(2+)-activated K(+) (SK) channels in colonic relaxation and the regulation of SK channels by estrogen.The contractile activity of muscle strips from male rats was estimated, and drugs including ... |
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Pharmacokinetics and tissue distribution study of novel potent antiplatelet agent S007-867 in mice using HPLC-MS/MS.
Xenobiotica 45 , 530-7, (2015) 1. S007-867 is a novel antiplatelet agent that shows promising in vitro and in vivo efficacy. For further development and better pharmacological elucidation, we characterized pharmacokinetics and tissue distribution of S007-867 in a mouse model. 2. A sensitiv... |