N-Methylmoranoline
N-Methylmoranoline structure
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Common Name | N-Methylmoranoline | ||
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| CAS Number | 69567-10-8 | Molecular Weight | 177.19800 | |
| Density | 1.394g/cm3 | Boiling Point | 367.2ºC at 760 mmHg | |
| Molecular Formula | C7H15NO4 | Melting Point | 126-128ºC | |
| MSDS | Chinese USA | Flash Point | 220.3ºC | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Rapid degradation of the heavy chain of class I major histocompatibility complex antigens in the endoplasmic reticulum of human cytomegalovirus-infected cells.
J. Virol. 68 , 7933, (1994) Human cytomegalovirus (HCMV) infection results in a marked reduction in the surface expression of class I major histocompatibility complex antigens on the host cells, which is thought to be one of the means for HCMV to evade the host immune system. To clarify... |
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Glucosidase and mannosidase inhibitors mediate increased secretion of mutant alpha1 antitrypsin Z.
J. Biol. Chem. 275(3) , 1987-92, (2000) It is now well known that the addition and trimming of oligosaccharide side chains during post-translational modification play an important role in determining the fate of secretory, membrane, and lysosomal glycoproteins. Recent studies have suggested that tr... |
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Evidence for processing of dolichol-linked oligosaccharides in patients with neuronal ceroid-lipofuscinosis.
Am. J. Med. Genet. 42(4) , 586-92, (1992) In agreement with reports from other laboratories, we have shown that patients with the juvenile or late infantile forms of neuronal ceroid-lipofuscinosis (NCL) have greatly increased levels (5-fold to 20-fold) of dolichyl pyrophosphoryl oligosaccharides in t... |
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Combination of N-methyl-1-deoxynojirimycin and ischemic preconditioning markedly reduces the size of myocardial infarcts in rabbits.
Jpn. Circ. J. 65(7) , 673-7, (2001) N-methyl-1-deoxynojirimycin (NMDN), an a-glucosidase inhibitor, reduces myocardial infarct size by reducing the glycogenolytic rate through inhibition of the alpha-1,6-glucosidase of glycogen-debranching enzyme in the heart, in addition to possessing an antih... |
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Expression of choline acetyltransferase activity in a co-culture of spinal cord and skeletal muscle cells is inhibited by myogenic differentiation inhibitors.
Brain Res. Dev. Brain Res. 60(2) , 133-6, (1991) The effect of myogenic differentiation on the expression of choline acetyltransferase (ChAT) activity in co-cultured spinal cord neurons was studied. ChAT activity in spinal cord cells dissociated from 14-day mouse embryos was markedly increased when co-cultu... |
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Role of protein kinase C in the reduction of infarct size by N-methyl-1-deoxynojirimycin, an alpha-1,6-glucosidase inhibitor.
Br. J. Pharmacol. 133(5) , 635-42, (2001) Preischaemic treatment with N-methyl-1-deoxynojirimycin (MOR-14), an alpha-1,6-glucosidase inhibitor, attenuates glycogenolysis and lactate accumulation during ischaemia and markedly reduces infarct size in rabbit hearts. In the present study, we have investi... |
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Effect of glycosidase inhibitors on the biosynthesis of alpha 2-plasmin inhibitor and antithrombin III in Hep G2 cells.
Biochim. Biophys. Acta 1226(3) , 300-6, (1994) We studied the effect of the glucosidase I inhibitor, N-methyl-1-deoxynojirimycin (MdN) and the mannosidase inhibitor, 1-deoxymannojirimycin (dMM) on the biosynthesis and secretion of alpha 2-plasmin inhibitor (alpha 2-PI) and antithrombin III (ATIII) in cult... |
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Effect of glycosylation inhibitors and acidotropic amines on the synthesis, processing, and intracellular-extracellular distribution of alpha-L-fucosidase in B-lymphoblastoid cells.
Carbohydr. Res. 197 , 217-26, (1990) N-Methyldeoxynojirimycin, 1-deoxymannojirimycin, and monensin interferred with normal processing of asparagine-linked oligosaccharide chains of alpha-L-fucosidase in lymphoid cells by blocking conversion of high-mannose oligosaccharides of newly made precurso... |
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Synthesis and characteristics in tumor-bearing mice of N-[11C]methyl-1-deoxynojirimycin and N-[11C]methyl-1-deoxymannojirimycin.
Nucl. Med. Biol. 20(7) , 843-7, (1993) N-[11C]Methyl-1-deoxynojirimycin ([11C]MDNM) and N-[11C]methyl-1-deoxymannojirimycin ([11C]MDMM) were prepared by 11C-methylation of 1-deoxynojirimycin (DNM) and 1-deoxymannojirimycin (DMM), which are specific inhibitors of glucosidase and mannosidase, respec... |