Pirarubicin
Pirarubicin structure
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Common Name | Pirarubicin | ||
|---|---|---|---|---|
| CAS Number | 72496-41-4 | Molecular Weight | 627.636 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 834.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C32H37NO12 | Melting Point | 188-192ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 458.6±34.3 °C | |
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Synthesis and therapeutic effect of styrene-maleic acid copolymer-conjugated pirarubicin.
Cancer Sci. 106(3) , 270-8, (2015) Previously, we prepared a pirarubicin (THP)-encapsulated micellar drug using styrene-maleic acid copolymer (SMA) as the drug carrier, in which active THP was non-covalently encapsulated. We have now developed covalently conjugated SMA-THP (SMA-THP conjugate) ... |
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Co-delivery of Pirarubicin and Paclitaxel by Human Serum Albumin Nanoparticles to Enhance Antitumor Effect and Reduce Systemic Toxicity in Breast Cancers.
Mol. Pharm. 12 , 4085-98, (2015) In our study, we aimed to develop a codelivery nanoparticulate system of pirarubicin (THP) and paclitaxel (PTX) (Co-AN) using human serum albumin to improve the therapeutic effect and reduce systemic toxicities. The prepared Co-AN demonstrated a narrow size d... |
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Porphyrin-adsorbed Allograft Bone: A Photoactive, Antibiofilm Surface.
Clin. Orthop. Relat. Res. 473 , 2865-73, (2015) Allograft bone is commonly used to augment bone stock. Unfortunately, allograft is prone to bacterial contamination and current antimicrobial therapies are inadequate. Photoactivated porphyrins combat bacterial growth by production of reactive oxygen species ... |
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Single adult kidney stem/progenitor cells reconstitute three-dimensional nephron structures in vitro.
Stem Cells 33(3) , 774-84, (2015) The kidneys are formed during development from two distinct primordial tissues, the metanephric mesenchyme and the ureteric bud. The metanephric mesenchyme develops into the kidney nephron, the minimal functional unit of the kidney. A nephron consists of seve... |
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Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy.
Oncotarget 6(8) , 6105-22, (2015) Androgen deprivation therapy induces apoptosis or cell cycle arrest in prostate cancer (PCa) cells. Here we set out to analyze whether MCL1, a known mediator of chemotherapy resistance regulates the cellular response to androgen withdrawal. Analysis of MCL1 p... |
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A yeast-based assay identifies drugs that interfere with immune evasion of the Epstein-Barr virus.
Dis. Model Mech. 7(4) , 435-44, (2014) Epstein-Barr virus (EBV) is tightly associated with certain human cancers, but there is as yet no specific treatment against EBV-related diseases. The EBV-encoded EBNA1 protein is essential to maintain viral episomes and for viral persistence. As such, EBNA1 ... |
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Pharmacokinetics and brain distribution of tetrahydropalmatine and tetrahydroberberine after oral administration of DA-9701, a new botanical gastroprokinetic agent, in rats.
Biol. Pharm. Bull. 38(2) , 285-91, (2015) DA-9701, a new botanical gastroprokinetic agent, has potential for the management of delayed gastric emptying in Parkinson's disease if it has no central anti-dopaminergic activity. Therefore, we examined the pharmacokinetics of DA-9701 components having dopa... |
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Validated UPLC-MS/MS method for simultaneous determination of simvastatin, simvastatin hydroxy acid and berberine in rat plasma: Application to the drug-drug pharmacokinetic interaction study of simvastatin combined with berberine after oral administration in rats.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1006 , 8-15, (2015) A rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay method was developed and validated for simultaneous quantification of simvastatin (SV), its metabolite simvastatin hydroxy acid (SVA) and berberine (BBR) in rat plasma. Sep... |
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A Maitland-Japp inspired synthesis of dihydropyran-4-ones and their stereoselective conversion to functionalised tetrahydropyran-4-ones.
Org. Biomol. Chem. 13(16) , 4743-50, (2015) The Maitland-Japp reaction has been extended to the synthesis of highly functionalised dihydropyran-4-ones. These dihydropyran-4-ones can in turn be converted stereoselectively into tetrahydropyran-4-ones with tertiary and quaternary stereocentres via the one... |
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EWS-FLI1 employs an E2F switch to drive target gene expression.
Nucleic Acids Res. 43(5) , 2780-9, (2015) Cell cycle progression is orchestrated by E2F factors. We previously reported that in ETS-driven cancers of the bone and prostate, activating E2F3 cooperates with ETS on target promoters. The mechanism of target co-regulation remained unknown. Using RNAi and ... |