Tiamulin

Tiamulin Structure
Tiamulin structure
Common Name Tiamulin
CAS Number 55297-95-5 Molecular Weight 493.742
Density 1.1±0.1 g/cm3 Boiling Point 563.0±50.0 °C at 760 mmHg
Molecular Formula C28H47NO4S Melting Point 147-148ºC
MSDS Chinese USA Flash Point 294.3±30.1 °C

[Effect of different compatibility of tetramethylpyrazine on its pharmacokinetics in vivo].

Zhongguo Zhong Yao Za Zhi 37(9) , 1311-4, (2012)

To study the pharmacokinetics of single administration and different compatibility of tetramethylpyrazine (TMP) in rats.Thirty two Sprague-Dawley rats were randomly divided into 4 groups: the TMP (30 mg x kg(-1)) group, the TMP+FA (30 mg x kg(-1) + 50 mg x kg...

Design, synthesis, and antibacterial activity of novel pleuromutilin derivatives bearing an amino thiazolyl ring.

Arch. Pharm. (Weinheim) 345(8) , 638-46, (2012)

A series of novel pleuromutilin derivatives containing the amino thiazolyl ring were designed, synthesized, and evaluated for their antibacterial activities in vitro against Gram-positive clinical bacteria. All the target compounds showed better aqueous solub...

Simultaneous determination of three classes of antibiotics in the suspended solids of swine wastewater by ultrasonic extraction, solid-phase extraction and liquid chromatography-mass spectrometry.

J. Environ. Sci. (China) 23(10) , 1729-37, (2011)

This work describes a systematic approach to the development of a method for simultaneous determination of three classes of veterinary antibiotics in the suspended solids (SS) of swine wastewater, including five sulfonamides, three tetracyclines and one macro...

Mutations in 23S rRNA gene associated with decreased susceptibility to tiamulin and valnemulin in Mycoplasma gallisepticum.

FEMS Microbiol. Lett. 308(2) , 144-9, (2010)

Mycoplasma gallisepticum is a major etiological agent of chronic respiratory disease (CRD) in chickens and sinusitis in turkeys. The pleuromutilin antibiotics tiamulin and valnemulin are currently used in the treatment of M. gallisepticum infection. We studie...

Compatibility of a combination of tiamulin and chlortetracycline with salinomycin in feed during a pulsed medication program coadministration in broilers.

Poult. Sci. 87(12) , 2528-34, (2008)

In an earlier study, the continuous medication of broiler feed with a combination of tiamulin (TIA; 20 mg/kg), chlortetracycline (CTC; 60 mg/kg), and the ionophore anticoccidial salinomycin (SAL; 60 mg/kg) caused an initial increase in BW and feed efficiency ...

Factors influencing the activity of tiamulin against Histomonas meleagridis in vitro.

Avian Dis. 54(2) , 936-8, (2010)

In this study, we investigated the activity of tiamulin fumerate against three strains of Histomonas meleagridis in vitro under different conditions. Tiamulin reduced histomonal growth of all three strains at concentrations of 20 ppm and higher. Cultures in p...

Tiamulin hydrogen fumarate--veterinary uses and HPLC method of determination in premixes and medicated feeding stuffs.

Acta Pol. Pharm. 67(6) , 682-5, (2010)

Decreased susceptibility of MRSA ST398 to tiamulin.

Vet. Microbiol. 151(3-4) , 422-3, (2011)

Spironucleosis in gamebirds.

Vet. Rec. 164(12) , 377, (2009)

Tiamulin activity against Brachyspira hyodysenteriae.

Vet. Rec. 163(25) , 760, (2008)