6-Nitroso-1,2-benzopyrone
6-Nitroso-1,2-benzopyrone structure
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Common Name | 6-Nitroso-1,2-benzopyrone | ||
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| CAS Number | 130506-22-8 | Molecular Weight | 175.14100 | |
| Density | 1.38g/cm3 | Boiling Point | 391.5ºC at 760mmHg | |
| Molecular Formula | C9H5NO3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 221.1ºC | |
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Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds.
Nature 361 , 473, (1993) Retroviral nucleocapsid and gag-precursor proteins from all known strains of retroviruses contain one or two copies of an invariant sequence, Cys-X2-Cys-X4-His-X4-Cys, that is populated with zinc in mature particles. Modification of cysteine or histidine resi... |
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Induction of endonuclease-mediated apoptosis in tumor cells by C-nitroso-substituted ligands of poly(ADP-ribose) polymerase.
Proc. Natl. Acad. Sci. U. S. A. 89(16) , 7703-7, (1992) 6-Nitroso-1,2-benzopyrone and 3-nitrosobenzamide, two C-nitroso compounds that inactivate the eukaryotic nuclear protein poly(ADP-ribose) polymerase [NAD+:poly(adenosine diphosphate D-ribose) ADP-D-ribosyltransferase, ADPRT, EC 2.4.2.30] at one zinc-finger si... |
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Destabilization of Zn2+ coordination in ADP-ribose transferase (polymerizing) by 6-nitroso-1,2-benzopyrone coincidental with inactivation of the polymerase but not the DNA binding function.
FEBS Lett. 290 , 181, (1991) 6-Nitroso-1,2-benzopyrone, an oxidation product of 6-amino-1,2-benzopyrone, binds to the DNA-recognizing domain of the ADP-ribose transferase protein and preferentially destabilizes Zn2+ from one of the two zinc finger polypeptide complexes present in the int... |
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Rapid and flexible biochemical assays for evaluating 4'-phosphopantetheinyl transferase activity.
Biochem. J. 436(3) , 709-17, (2011) PPTases (phosphopantetheinyl transferases) are of great interest owing to their essential roles in activating fatty acid, polyketide and non-ribosomal peptide synthetase enzymes for both primary and secondary metabolism, as well as an increasing number of bio... |