Hexan-1,6-diol
Hexan-1,6-diol structure
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Common Name | Hexan-1,6-diol | ||
|---|---|---|---|---|
| CAS Number | 629-11-8 | Molecular Weight | 118.174 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 239.7±8.0 °C at 760 mmHg | |
| Molecular Formula | C6H14O2 | Melting Point | 40-43ºC | |
| MSDS | Chinese USA | Flash Point | 101.7±0.0 °C | |
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Self-immolative polycations as gene delivery vectors and prodrugs targeting polyamine metabolism in cancer.
Mol. Pharm. 12(2) , 332-41, (2015) Polycations are explored as carriers to deliver therapeutic nucleic acids. Polycations are conventionally pharmacological inert with the sole function of delivering therapeutic cargo. This study reports synthesis of a self-immolative polycation (DSS-BEN) base... |
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Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins
Bioorg. Med. Chem. 17 , 896-904, (2009) This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the mole... |
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Flavonoid-based pH-responsive hydrogels as carrier of unstable drugs in oxidative conditions.
Pharm. Dev. Technol. 20(3) , 288-96, (2015) In this study, pH-responsive hydrogels, synthesized by the coupling reaction of polyacrylic acid and catechin, are proposed as carriers of oxidable drugs toward the GI tract. The presence of polyphenolic moieties in the network gives the polymers properties s... |
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Nuclease resistance and RNase H sensitivity of oligonucleotides bridged by oligomethylenediol and oligoethylene glycol linkers.
Antisense Nucleic Acid Drug Dev. 11(2) , 77-85, (2001) The properties of new chimeric oligodeoxynucleotides made of short sequences (tetramers, pentamers, octamers, and decamers) bridged by hexamethylenediol and hexaethylene glycol linkers have been investigated. These chimeric oligonucleotides showed an improved... |
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The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death.
Cell Death Dis. 6 , e1616, (2015) The selenoprotein thioredoxin reductase 1 (TrxR1) has several key roles in cellular redox systems and reductive pathways. Here we discovered that an evolutionarily conserved and surface-exposed tryptophan residue of the enzyme (Trp114) is excessively reactive... |
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Arabidopsis replacement histone variant H3.3 occupies promoters of regulated genes.
Genome Biol. 15(4) , R62, (2014) Histone variants establish structural and functional diversity of chromatin by affecting nucleosome stability and histone-protein interactions. H3.3 is an H3 histone variant that is incorporated into chromatin outside of S-phase in various eukaryotes. In anim... |
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Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules.
Elife 4 , e06807, (2015) RNA-protein (RNP) granules have been proposed to assemble by forming solid RNA/protein aggregates or through phase separation into a liquid RNA/protein phase. Which model describes RNP granules in living cells is still unclear. In this study, we analyze P bod... |
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Simultaneous extraction of flavonoids from Chamaecyparis obtusa using deep eutectic solvents as additives of conventional extractions solvents.
J. Chromatogr. Sci. 53 , 836-40, (2015) Three flavones (quercetin, myricetin and amentoflavone) were extracted from Chamaecyparis obtusa leaves using deep eutectic solvents (DESs) as additives to conventional extractions solvents. Sixteen DESs were synthesized from different salts and hydrogen bond... |
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Determination of leachable components from four commercial dental composites by gas and liquid chromatography/mass spectrometry.
J. Dent. 26(2) , 137-45, (1998) The purpose of our study was to determine the quality and quantity of leachable residual (co)monomers and additives eluted from various commercial dental composite resins after polymerization.Polymerized specimens from four universal hybrid-type composite res... |
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Activity of lactate dehydrogenase isoenzymes LD1 and LD2 in serum as determined by using an inhibitor of the M-subunit.
Clin. Chem. 31(7) , 1175-7, (1985) To measure activities of lactate dehydrogenase (EC 1.1.1.27) isoenzymes LD1 and LD2 in serum, we developed a method involving 1,6-hexanediol as specific inhibitor of the M-subunit. Addition of hexanediol, 0.6 mol/L, to five LD isoenzyme fractions purified fro... |