(2-Hydroxypropyl)-γ-cyclodextrin
(2-Hydroxypropyl)-γ-cyclodextrin structure
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Common Name | (2-Hydroxypropyl)-γ-cyclodextrin | ||
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| CAS Number | 128446-34-4 | Molecular Weight | 1587.521 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 97-98ºC3 mm Hg(lit.) | |
| Molecular Formula | C7H6FNO2 | Melting Point | 52-55ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | >230 °F | |
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When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: Effects of pretreatment with 5-HT1A and dopamine D2 antagonists
Neuroscience 154 , 1619-26, (2008) When given in a warm environment MDMA (3,4-methylenedioxymethamphetamine, ecstasy) causes hyperthermia by increasing interscapular brown adipose tissue (iBAT) heat production and decreasing heat loss via cutaneous vasoconstriction. When given in a cold enviro... |
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Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking.
Eur. J. Neurosci. 30 , 493-503, (2009) The orexin/hypocretin system has recently been implicated in reward-processing and addiction. We examined the involvement of the orexin system in cue-induced reinstatement of extinguished cocaine-seeking by administering the orexin 1 receptor antagonist SB-33... |
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The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.
Cell Death Differ. 14 , 743-51, (2007) Upon DNA damage signaling, p73, a member of the p53 tumor suppressor family, accumulates to support transcription of downstream apoptotic genes. p73 interacts with Yes-associated protein 1 (Yap1) through its PPPY motif, and increases p73 transactivation of ap... |
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Modulation of response to radiation of human lung cancer cells following insulin-like growth factor 1 receptor inactivation.
Cancer Lett. 222 , 173-81, (2005) Targeted disruption of the insulin-like growth factor 1 receptor (IGF-1R) restricts proliferation of tumor cells and enhances their in vitro radiosensitivity. However, there is little information regarding the effect of IGF-1R expression and function on the l... |
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Cyclodextrin Drug Carrier Systems.
Chem. Rev. 98 , 2045-2076, (1998)
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Complexation Thermodynamics of Cyclodextrins.
Chem. Rev. 98 , 1875-1917, (1998)
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The topoisomerase II-Hsp90 complex: a new chemotherapeutic target?
Int. J. Cancer 118 , 2685-93, (2006) The modulation of DNA topology by topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and has thus become a highly attractive target for chemotherapeutic drugs. However, these drugs are highly toxic, and so new appr... |
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Allelic methylation bias of the RARB2 tumor suppressor gene promoter in cancer.
Genes Chromosomes Cancer 47 , 978-93, (2008) Retinoic acid receptor B2 (RARB2) is frequently inactivated in cancer. Methylation in the 5'-untranslated region and first exon is known to play a role; however, few studies have analyzed the detailed methylation pattern of the promoter region. We show that h... |
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The utility of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs.
Life Sci. 48 , 623-633, (1991) The substituted glucopyranose ring structure 2-hydroxypropyl-beta-cyclodextrin (CDEX) increases the solubility of molecules by inclusion of the agent in the lipophilic interior of the ring. This property is of particular use for the administration of molecule... |
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The phosphatidylinositol 3-kinase-mediated production of interferon-beta is critical for the lipopolysaccharide inhibition of osteoclastogenesis.
Life Sci. 83 , 369-76, (2008) This study was performed to define molecular mechanisms underlying lipopolysaccharide (LPS)-induced inhibition of osteoclastogenesis.The LPS-dependent signaling pathways leading to the inhibition of osteoclastogenesis were examined using chemical inhibitors a... |