![]() 2-(4-BIPHENYLYL)-5-PHENYL-1,3,4-OXADIAZOLE structure
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Common Name | 2-(4-BIPHENYLYL)-5-PHENYL-1,3,4-OXADIAZOLE | ||
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CAS Number | 852-38-0 | Molecular Weight | 298.33800 | |
Density | 1.172g/cm3 | Boiling Point | 480.7ºC at 760 mmHg | |
Molecular Formula | C20H14N2O | Melting Point | 167-169 °C(lit.) | |
MSDS | Chinese USA | Flash Point | 240.7ºC |
Cytohesin 2/ARF6 regulates preadipocyte migration through the activation of ERK1/2.
Biochem. Pharmacol. 92(4) , 651-60, (2015) Preadipocyte migration is vital for the development of adipose tissue, which plays a crucial role in lipid metabolism. ADP-ribosylation factor 6 (ARF6) small GTPase, which regulates membrane trafficking, is activated by GTP-exchange factors (GEFs) such as cyt... |
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mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis.
PLoS Genet. 11 , e1005291, (2015) Akt phosphorylation is a major driver of cell survival, motility, and proliferation in development and disease, causing increased interest in upstream regulators of Akt like mTOR complex 2 (mTORC2). We used genetic disruption of Rictor to impair mTORC2 activi... |
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Suppression of chemotaxis by SSeCKS via scaffolding of phosphoinositol phosphates and the recruitment of the Cdc42 GEF, Frabin, to the leading edge.
PLoS ONE 9(10) , e111534, (2014) Chemotaxis is controlled by interactions between receptors, Rho-family GTPases, phosphatidylinositol 3-kinases, and cytoskeleton remodeling proteins. We investigated how the metastasis suppressor, SSeCKS, attenuates chemotaxis. Chemotaxis activity inversely c... |
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Toxicogenetic effects of low concentrations of the pesticides imidacloprid and sulfentrazone individually and in combination in in vitro tests with HepG2 cells and Salmonella typhimurium.
Ecotoxicol. Environ. Saf. 120 , 174-83, (2015) The insecticide imidacloprid and the herbicide sulfentrazone are two different classes of pesticides that are used for pest control in sugarcane agriculture. To evaluate the genotoxic potential of low concentrations of these two pesticides alone and in mixtur... |
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Streamlined determination of lysophosphatidylcholines in dried blood spots for newborn screening of X-linked adrenoleukodystrophy.
Mol. Genet. Metab. 114(1) , 46-50, (2014) Pre-symptomatic hematopoietic stem cell transplantation is essential to achieve best possible outcomes for patients with the childhood cerebral form of X-linked adrenoleukodystrophy (X-ALD). We describe a high-throughput method for measurement of C20-C26 lyso... |
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Antibody structural integrity of site-specific antibody-drug conjugates investigated by hydrogen/deuterium exchange mass spectrometry.
Anal. Chem. 87 , 5669-76, (2015) We present the results of a hydrogen/deuterium exchange mass spectrometric (HDX-MS) investigation of an antibody-drug conjugate (ADC) comprised of drug-linkers conjugated to cysteine residues that have been engineered into heavy chain (HC) fragment crystalliz... |
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cAMP Promotes Cell Migration Through Cell Junctional Complex Dynamics and Actin Cytoskeleton Remodeling: Implications in Skin Wound Healing.
Stem Cells Dev. 24 , 2513-24, (2015) Stem cells have attracted great interest for their therapeutic capacity in tissue regeneration. Cyclic adenosine 3',5'-monophosphate (cAMP), existing in high concentration at wound sites, mediated various signaling pathways such as cytoskeleton dynamics, cell... |
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Crucial roles of TNFAIP8 protein in regulating apoptosis and Listeria infection.
J. Immunol. 194 , 5743-50, (2015) TNF-α-induced protein 8 (TNFAIP8 or TIPE) is a newly described regulator of cancer and infection. However, its precise roles and mechanisms of actions are not well understood. We report in this article that TNFAIP8 regulates Listeria monocytogenes infection b... |
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TIPE2 protein prevents injury-induced restenosis in mice.
Biochim. Biophys. Acta 1852 , 1574-84, (2015) Proliferation of vascular smooth muscle cells (VSMCs) plays an important role in restenosis, a disease characterized by smooth muscle cell hyperplasia and neointimal formation. How proliferation signals are controlled to avoid restenosis is not fully understo... |
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The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.
Transl. Oncol. 7(5) , 546-55, (2014) Metastatic disease still lacks effective treatments, and remains the primary cause of cancer mortality. Therefore, there is a critical need to develop better strategies to inhibit metastatic cancer. The Rho family GTPase Rac is an ideal target for anti-metast... |