fluspirilene
fluspirilene structure
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Common Name | fluspirilene | ||
|---|---|---|---|---|
| CAS Number | 1841-19-6 | Molecular Weight | 475.573 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 668.9±55.0 °C at 760 mmHg | |
| Molecular Formula | C29H31F2N3O | Melting Point | 187.5-190° | |
| MSDS | Chinese USA | Flash Point | 358.3±31.5 °C | |
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Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Proc. Natl. Acad. Sci. U. S. A. 104 , 19023-8, (2007) Autophagy is a lysosome-dependent cellular catabolic mechanism mediating the turnover of intracellular organelles and long-lived proteins. Reduction of autophagy activity has been shown to lead to the accumulation of misfolded proteins in neurons and may be i... |
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Determination of fluspirilene in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionisation.
J. Chromatogr. A. 828(1-2) , 219-27, (1998) An ultra-sensitive method for the determination of fluspirilene in plasma was established, using high-performance liquid chromatographic separation with tandem mass spectrometric detection. The samples were extracted with hexane/isoamyl alcohol, separated on ... |
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Test therapy in the treatment of generalized anxiety disorders with low dose fluspirilene.
Prog. Neuropsychopharmacol. Biol. Psychiatry 19(6) , 1049-60, (1995) 1. The present double-blind study was designed to determine under three different conditions (0.5 mg, 1.0 mg, 1.5 mg per week) whether response or non-response within a two-week test-therapy predicts clinical outcome after 6 weeks of fluspirilene treatment in... |
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A crystallographic and molecular modeling study of butyrophenones.
J. Pharm. Sci. 87(12) , 1496-501, (1998) The X-ray crystal structures of four butyrophenone analogues have been completed and are reported herein. These include spiperone hydrochloride (I), N-methylspiperone hydrochloride (II), pimozide (III), and fluspirilene (IV). These structures were compared to... |
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Grief hallucinations: true or pseudo? Serious or not? An inquiry into psychopathological and clinical features of a common phenomenon.
Psychopathology 35(5) , 296-302, (2002) An inquiry into the psychopathology and the clinical significance of grief hallucinations is presented and two cases with severe grief hallucinations are described. Unlike many cases in the literature, the two female patients were young (aged 43 and 45, respe... |
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Stable expression and characterization of the human brain potassium channel Kv2.1: blockade by antipsychotic agents.
Brain Res. 761(1) , 42-50, (1997) We have cloned the cDNA encoding the voltage-dependent K+ channel Kv2.1 from human brain (hKv2.1). RNase protection and RT-PCR (reverse transcriptase-PCR) experiments reveal abundant Kv2.1 transcripts in human brain with virtually no expression detectable in ... |
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Inhibition of glutamate release by fluspirilene in cerebrocortical nerve terminals (synaptosomes).
Synapse 44(1) , 36-41, (2002) Fluspirilene, a neuroleptic drug which is used clinically to treat schizophrenic patients, is a dopamine D2 receptor antagonist. Besides its well-known actions on the dopamine receptors, fluspirilene also displays calcium channel-blocking activity. The aim of... |
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[Interaction of therapeutic effects and side effects in drug therapy of generalized anxiety disorders with low dosage fluspirilene].
Fortschr. Neurol. Psychiatr. 63(2) , 72-7, (1995) The present study was designed to investigate the interaction between therapeutic effects and side-effects in fluspirilene treatment of generalised anxiety disorders (GAD). 205 outpatients received in an open trial 1.5 mg fluspirilene per week for 6 weeks. Co... |
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[Fluspirilene--safe weekly tranquilizer?].
Nervenarzt 68(6) , 528, (1997)
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Re: Rapid stabilization at home.
Can. J. Psychiatry. 42(4) , 427, (1997)
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