KT5823
KT5823 structure
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Common Name | KT5823 | ||
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| CAS Number | 126643-37-6 | Molecular Weight | 495.52600 | |
| Density | 1.52g/cm3 | Boiling Point | 629.2ºC at 760mmHg | |
| Molecular Formula | C29H25N3O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 334.3ºC | |
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Brain natriuretic peptide constitutively downregulates P2X3 receptors by controlling their phosphorylation state and membrane localization.
Mol. Pain 11 , 71, (2015) ATP-gated P2X3 receptors are important transducers of nociceptive stimuli and are almost exclusively expressed by sensory ganglion neurons. In mouse trigeminal ganglion (TG), P2X3 receptor function is unexpectedly enhanced by pharmacological block of natriure... |
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Interaction between bradykinin and natriuretic peptides via RGS protein activation in HEK-293 cells.
Am. J. Physiol. Cell Physiol. 303(12) , C1260-8, (2012) In this study, the interaction of natriuretic peptides (NP) and bradykinin (BK) signaling pathways was identified by measuring membrane potential (V(m)) and intracellular Ca(2+) using the patch-clamp technique and flow cytometry in HEK-293 cells. BK and NP re... |
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Cytoprotective effect of 1-nitro-2-phenylethane in mice pancreatic acinar cells subjected to taurocholate: putative role of guanylyl cyclase-derived 8-nitro-cyclic-GMP.
Biochem. Pharmacol. 91(2) , 191-201, (2014) The nitroderivative 1-nitro-2-phenylethane (NPE) was recently described as a compound possessing heme-dependent soluble guanylyl cyclase (sGC) stimulating properties in vascular smooth muscle cells. In this study, we tested such pharmacological property of NP... |
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Protective effects of brain-derived neurotrophic factor against neurotoxicity of 3-nitropropionic acid in rat cortical neurons.
Neurotoxicology 30 , 718-26, (2009) Brain-derived neurotrophic factor (BDNF) deficiency has been implicated in pathogenesis of Huntington's disease (HD). 3-Nitropropionic acid (3-NP), an irreversible mitochondrial complex II inhibitor, has been commonly used as a pharmacological model recapitul... |
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Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
J. Nat. Prod. 75(5) , 896-904, (2012) Kaurenoic acid [ent-kaur-16-en-19-oic acid (1)] is a diterpene present in several plants including Sphagneticola trilobata. The only documented evidence for its antinociceptive effect is that it inhibits the writhing response induced by acetic acid in mice. T... |
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Hypoxia-inducible factor 1 regulation through cross talk between mTOR and MT1-MMP.
Mol. Cell. Biol. 34(1) , 30-42, (2014) Hypoxia-inducible factor 1 (HIF-1) plays a key role in the cellular adaptation to hypoxia. Although HIF-1 is usually strongly suppressed by posttranslational mechanisms during normoxia, HIF-1 is active and enhances tumorigenicity in malignant tumor cells that... |
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Colitis generates remote antinociception in rats: the role of the L-arginine/NO/cGMP/PKG/KATP pathway and involvement of cannabinoid and opioid systems.
Inflamm. Res. 63(12) , 969-77, (2014) The aim of this study was to investigate the possible involvement of the NO/cGMP/PKG/KATP+ pathway, cannabinoids and opioids in remote antinociception associated with 2,4,6-trinitrobenzene sulph onic acid (TNBS)-induced colitis.TNBS-induced colitis was induce... |
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PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition.
Neurobiol. Aging 35(9) , 2072-8, (2014) The cyclic nucleotide cGMP is an important intracellular messenger for synaptic plasticity and memory function in rodents. Therefore, inhibition of cGMP degrading phosphodiesterases, like PDE9A, has gained interest as potential target for treatment of cogniti... |
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Spermidine decreases Na+,K+-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats
Eur. J. Pharmacol. 684(1-3) , 79-86, (2012) Spermidine is an endogenous polyamine with a polycationic structure present in the central nervous system of mammals. Spermidine regulates biological processes, such as Ca2+ influx by glutamatergic N-methyl-d-aspartate receptor (NMDA receptor), which has been... |
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Vasonatrin peptide, a new regulator of adiponectin and interleukin-6 production in adipocytes.
J. Endocrinol. Invest. 34(10) , 742-6, (2011) In addition to lipolytic function, ANP plays regulatory roles in the production of various adipokines including adiponectin, leptin, and interleukins. However, the adipose effects of vasonatrin peptide (VNP), a new manmade natriuretic peptide, are largely unk... |